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An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects
NCT04112992 · View on ClinicalTrials.gov ↗
Study Summary
Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group. Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations. In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.
Conditions Studied
Interventions
- PROCEDURE Any treatment that is used for a defect of any long bone
Study Locations (20)
Other
- John Hunter Hospital — Newcastle
- Hospital Municipal Miguel Couto Serviço de Ortopedia e Traumatologia — Rio de Janeiro
- Hospital Base Valdivia — Valdivia
- Hospital Universitario de la Samaritana — Bogotá
- Hospital Pablo Tobon Uribe — Medellín
- University Hospital Frankfurt — Frankfurt
- Universitätsspital Gießen — Giessen
- Universitätsklinikum Heidelberg (Unfallchirurgie) — Heidelberg
- Universitätsklinikum Münster (Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie) — Münster
- Krankenhaus Johanneum — Wildeshausen
- Paras HMRI Hospital Patna — Patna
- Academisch Ziekenhuis Maastricht (Dept. of Surgery) — Maastricht
- Radboud University Medical Center — Nijmegen
- Tygerberg Hospital — Cape Town
- Kyungpook National University Hospital (Orthopaedics) — Daegu
- Universitätsspital Zürich (Klinik für Traumatologie) — Zurich
- Central Hospital of Border Guard Service of Ukraine — Kyiv
- Leeds General Infirmary University Hospital (Trauma & Orthopaedic Surgery) — Leeds
California
- Cedar Sinai — Los Angeles
Maryland
- Sinai Hospital of Baltimore — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2024-07-03 |
| Est. Completion | 2029-03-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04112992
The ClinicalTrials.gov registry entry for NCT04112992 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AO Innovation Translation Center, which has 13 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Bone Loss appearing as the primary indexed condition, and to 1 intervention — of which Any treatment that is used for a defect of any long bone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04112992 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Other, California, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04112992 about?
NCT04112992 is a clinical study titled "An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects". Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the ...
What is the current status of trial NCT04112992?
This trial is currently recruiting. The enrollment target is 600 participants. The study started on 2024-07-03. Estimated completion is 2029-03-30.
What conditions does trial NCT04112992 study?
This clinical trial studies the following conditions: Bone Loss, Limb Fracture. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04112992?
The interventions under investigation include: Any treatment that is used for a defect of any long bone (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04112992?
This trial is sponsored by AO Innovation Translation Center, which has 13 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04112992 being conducted?
This trial has 20 study locations across California, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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