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NCT04112992 · ClinicalTrials.gov registry record
An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects
A clinical trial of Bone Loss and Limb Fracture, sponsored by AO Innovation Translation Center.
- Recruiting
- Registry status
- 600
- Enrollment target
- 20
- Study locations
NCT04112992: Recruiting study of Bone Loss and Limb Fracture, sponsored by AO Innovation Translation Center.
NCT04112992 is a study of Bone Loss and Limb Fracture that is actively recruiting participants, run by AO Innovation Translation Center. The registered enrollment target is 600 participants, above the 217-participant average among 16 other Bone Loss trials with a reported enrollment target (176% higher). The trial reports 20 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04112992, a study of Bone Loss and Limb Fracture, is actively recruiting participants, sponsored by AO Innovation Translation Center.
- RECRUITING
- Registry status
- 600 participants
- Enrollment target
- 20
- Study locations
Study Summary
Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group. Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations. In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.
Primary Outcome
Demographics, medical history, comorbidity
Conditions Studied
Interventions
- PROCEDURE Any treatment that is used for a defect of any long bone
Study Locations (20)
Other
- John Hunter Hospital - Newcastle
- Hospital Municipal Miguel Couto Serviço de Ortopedia e Traumatologia - Rio de Janeiro
- Hospital Base Valdivia - Valdivia
- Hospital Universitario de la Samaritana - Bogotá
- Hospital Pablo Tobon Uribe - Medellín
- University Hospital Frankfurt - Frankfurt
- Universitätsspital Gießen - Giessen
- Universitätsklinikum Heidelberg (Unfallchirurgie) - Heidelberg
- Universitätsklinikum Münster (Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie) - Münster
- Krankenhaus Johanneum - Wildeshausen
- Paras HMRI Hospital Patna - Patna
- Academisch Ziekenhuis Maastricht (Dept. of Surgery) - Maastricht
- Radboud University Medical Center - Nijmegen
- Tygerberg Hospital - Cape Town
- Kyungpook National University Hospital (Orthopaedics) - Daegu
- Universitätsspital Zürich (Klinik für Traumatologie) - Zurich
- Central Hospital of Border Guard Service of Ukraine - Kyiv
- Leeds General Infirmary University Hospital (Trauma & Orthopaedic Surgery) - Leeds
California
- Cedar Sinai - Los Angeles
Maryland
- Sinai Hospital of Baltimore - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2024-07-03 |
| Est. Completion | 2029-03-30 |
What NCT04112992 shows while recruiting
NCT04112992 is an observational study that tracks outcomes without assigning an intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, above the 217-participant average among 16 other Bone Loss trials with a reported enrollment target (176% higher).
The record links to 2 conditions, with Bone Loss appearing as the primary indexed condition, and to 1 intervention - of which Any treatment that is used for a defect of any long bone is the first listed.
NCT04112992 names 20 study sites across 3 states, led by Other, California, Maryland.
Frequently Asked Questions
What is clinical trial NCT04112992 about?
NCT04112992 is a clinical study titled "An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects". Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the ...
What is the current status of trial NCT04112992?
This trial is currently recruiting. The enrollment target is 600 participants. The study started on 2024-07-03. Estimated completion is 2029-03-30.
What conditions does trial NCT04112992 study?
This clinical trial studies the following conditions: Bone Loss, Limb Fracture.
What interventions are being tested in trial NCT04112992?
The interventions under investigation include: Any treatment that is used for a defect of any long bone (PROCEDURE).
Who is sponsoring clinical trial NCT04112992?
This trial is sponsored by AO Innovation Translation Center, which has 18 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04112992 being conducted?
This trial has 20 study locations across California, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04112992's enrollment target sits among peer trials
600 3rd of 16 higher than 14 of 16 other Bone Loss trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bone Loss trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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