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NCT06962488 · ClinicalTrials.gov registry record · NA
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
A NA study of Hypertension and Atherosclerotic Cardiovascular Disease, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT06962488: Recruiting NA study of Hypertension and Atherosclerotic Cardiovascular Disease, sponsored by University of Alabama at Birmingham.
NCT06962488 is a NA study of Hypertension and Atherosclerotic Cardiovascular Disease that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 300 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06962488, a NA study of Hypertension and Atherosclerotic Cardiovascular Disease, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse cardiovascular events beyond traditional risk factors. Delivering SBP PRS information to young and middle-aged adults with hypertension (HTN) and poor cardiovascular health (CVH) may enhance their motivation to adopt healthier lifestyles, improve blood pressure control, and ultimately reduce the risk of future cardiovascular disease (CVD). This randomized controlled trial will assess the impact of SBP PRS disclosure and theory-based genomic counseling on systolic blood pressure and health behaviors. A total of 300 adults aged 18-55 years will be enrolled and randomized to receive either routine clinical care or SBP PRS results with structured genomic counseling based on the Health Belief Model (HBM). Participants will be followed for 12 months. The primary outcome is change in 24-hour mean SBP from baseline to one year. Secondary outcomes include changes in physical activity, diet, medication adherence, smoking, lipid and glucose levels, and body composition. The study will also evaluate how behavior change is influenced by health beliefs, including perceived risk and self-efficacy. This study aims to advance the use of genomic tools in hypertension management and cardiovascular disease prevention.
Primary Outcome
The difference in the 24-hour mean systolic BP between the two study groups at 1 year, adjusted for baseline.
Conditions Studied
Interventions
- BEHAVIORAL Regular Care
- BEHAVIORAL SBP PRS Dissemination
Study Locations (1)
Alabama
- University of Alabama at Birmingham - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2025-08-01 |
| Est. Completion | 2030-07-31 |
| Phase | NA |
What NCT06962488 shows while recruiting
NCT06962488 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Regular Care is the first listed.
NCT06962488 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT06962488 about?
NCT06962488 is a clinical study titled "Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure". In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse cardiovascular events beyond traditional risk factors. Delivering SBP PRS info...
What is the current status of trial NCT06962488?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2025-08-01. Estimated completion is 2030-07-31.
What conditions does trial NCT06962488 study?
This clinical trial studies the following conditions: Hypertension, Atherosclerotic Cardiovascular Disease.
What interventions are being tested in trial NCT06962488?
The interventions under investigation include: Regular Care (BEHAVIORAL), SBP PRS Dissemination (BEHAVIORAL).
Who is sponsoring clinical trial NCT06962488?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06962488 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06962488's enrollment target sits among peer trials
300 170th of 470 higher than 291 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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