Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02746874 · ClinicalTrials.gov registry record · NA
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
A NA study of Arthroplasty, Replacement, Knee, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT02746874: Completed NA study of Arthroplasty, Replacement, Knee, sponsored by Northwestern University.
NCT02746874 is a NA study of Arthroplasty, Replacement, Knee that has completed, run by Northwestern University. The registered enrollment target is 70 participants, below the 197-participant average among 12 other Arthroplasty, Replacement, Knee trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02746874, a NA study of Arthroplasty, Replacement, Knee, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid diseases like sleep apnea, can be challenging and often require a multidisciplinary, multimodal approach. Opiates have been a mainstay of treatment in the post-operative period with varying degrees of success and complications. Inadequately controlled postoperative pain is not uncommon. Poorly controlled pain inhibits early mobilization and hinders post-operative physical therapy. A new paradigm for treating post-operative pain following total knee replacement may be the use of cooled radiofrequency ablation (C-RFA) of the articular sensory nerve supply of the knee capsule prior to surgery, to desensitize the knee by blocking sensory afferents to the anterior capsule and thereby decrease post-operative pain. There are several publications that have demonstrated the use of RFA in patients with chronic knee pain from osteoarthritis however the use of RFA in the preoperative management of pain in patients undergoing total knee joint replacement has not been investigated. The aim of this study is to determine if patients undergoing unilateral total knee replacement obtain any post-operative pain relieving benefits from C-RFA of the articular sensory nerve supply when performed prior to surgery, as compared to sham controls who receive only local anesthetic injections of these same nerves without the benefit of ablation treatment.
Primary Outcome
Pain medication will be calculated into oral morphine equivalents (ME) for the first 48 hours after surgery. Morphine equivalents determine a patient's cumulative intake of any drugs in the opioid class.
Conditions Studied
Interventions
- PROCEDURE Radiofrequency Ablation (RFA)
- PROCEDURE Simulated Radiofrequency Ablation (RFA)
Study Locations (1)
Illinois
- Anesthesiology Pain Medicine Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2016-12-01 |
| Est. Completion | 2017-12-31 |
| Phase | NA |
What the finished NCT02746874 record still lists
NCT02746874 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 197-participant average among 12 other Arthroplasty, Replacement, Knee trials with a reported enrollment target (64% lower).
The record links to 1 condition, with Arthroplasty, Replacement, Knee appearing as the primary indexed condition, and to 2 interventions - of which Radiofrequency Ablation (RFA) is the first listed.
NCT02746874 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT02746874 about?
NCT02746874 is a clinical study titled "Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes". More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid diseases like sleep apnea, can be challenging and often require a multi...
What is the current status of trial NCT02746874?
This trial is currently completed. It is a NA study. The enrollment target is 70 participants. The study started on 2016-12-01. Estimated completion is 2017-12-31.
What conditions does trial NCT02746874 study?
This clinical trial studies the following conditions: Arthroplasty, Replacement, Knee.
What interventions are being tested in trial NCT02746874?
The interventions under investigation include: Radiofrequency Ablation (RFA) (PROCEDURE), Simulated Radiofrequency Ablation (RFA) (PROCEDURE).
Who is sponsoring clinical trial NCT02746874?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02746874 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Arthroplasty, Replacement, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02746874's enrollment target sits among peer trials
70 9th of 12 higher than 4 of 12 other Arthroplasty, Replacement, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Arthroplasty, Replacement, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Real-component Vs All-cement Articulating Spacers for Periprosthetic Knee Infection
RECRUITING · NA
-
A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery
RECRUITING · NA
-
TracPatch in Total Knee Arthroplasty
ACTIVE NOT RECRUITING · NA
-
Music Therapy Versus Control for Total Knee Arthroplasty
COMPLETED · NA
-
Traditional vs Oral Fluid Management in Total Knee Arthroplasty
COMPLETED · NA
-
X-3 Polyethylene Survival Outcomes Study
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00969111 · 70 participants · NA
Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy
- NCT01712620 · 70 participants · Phase 2
Spironolactone for Pulmonary Arterial Hypertension
- NCT02143830 · 70 participants · Phase 2
HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
- NCT02601339 · 70 participants
NIRS Monitoring in Premature Infants
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI