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NCT02746874 · ClinicalTrials.gov registry record · NA
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
A NA study of Arthroplasty, Replacement, Knee, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT02746874 is a NA study of Arthroplasty, Replacement, Knee that has completed, run by Northwestern University. The registered enrollment target is 70 participants, below the 197-participant average among 12 other Arthroplasty, Replacement, Knee trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state.
The verdict
NCT02746874, a NA study of Arthroplasty, Replacement, Knee, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid diseases like sleep apnea, can be challenging and often require a multidisciplinary, multimodal approach. Opiates have been a mainstay of treatment in the post-operative period with varying degrees of success and complications. Inadequately controlled postoperative pain is not uncommon. Poorly controlled pain inhibits early mobilization and hinders post-operative physical therapy. A new paradigm for treating post-operative pain following total knee replacement may be the use of cooled radiofrequency ablation (C-RFA) of the articular sensory nerve supply of the knee capsule prior to surgery, to desensitize the knee by blocking sensory afferents to the anterior capsule and thereby decrease post-operative pain. There are several publications that have demonstrated the use of RFA in patients with chronic knee pain from osteoarthritis however the use of RFA in the preoperative management of pain in patients undergoing total knee joint replacement has not been investigated. The aim of this study is to determine if patients undergoing unilateral total knee replacement obtain any post-operative pain relieving benefits from C-RFA of the articular sensory nerve supply when performed prior to surgery, as compared to sham controls who receive only local anesthetic injections of these same nerves without the benefit of ablation treatment.
Conditions Studied
Interventions
- PROCEDURE Radiofrequency Ablation (RFA)
- PROCEDURE Simulated Radiofrequency Ablation (RFA)
Study Locations (1)
Illinois
- Anesthesiology Pain Medicine Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2016-12-01 |
| Est. Completion | 2017-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02746874
The ClinicalTrials.gov registry entry for NCT02746874 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 197-participant average among 12 other Arthroplasty, Replacement, Knee trials with a reported enrollment target (64% lower). The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Arthroplasty, Replacement, Knee appearing as the primary indexed condition, and to 2 interventions - of which Radiofrequency Ablation (RFA) is the first listed.
NCT02746874 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.
Frequently Asked Questions
What is clinical trial NCT02746874 about?
NCT02746874 is a clinical study titled "Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes". More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid diseases like sleep apnea, can be challenging and often require a multi...
What is the current status of trial NCT02746874?
This trial is currently completed. It is a NA study. The enrollment target is 70 participants. The study started on 2016-12-01. Estimated completion is 2017-12-31.
What conditions does trial NCT02746874 study?
This clinical trial studies the following conditions: Arthroplasty, Replacement, Knee.
What interventions are being tested in trial NCT02746874?
The interventions under investigation include: Radiofrequency Ablation (RFA) (PROCEDURE), Simulated Radiofrequency Ablation (RFA) (PROCEDURE).
Who is sponsoring clinical trial NCT02746874?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02746874 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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