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ClinicalTrials.gov 10 recruiting now official registry

ARDS clinical trials

10 of 15 indexed ARDS trials are currently recruiting.

15 US clinical trials · 10 currently recruiting

ARDS is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is PPD Development, running 4 of these trials.

The research picture

ARDS has 15 registered US clinical trials, 10 of them open to new participants right now, about 67% of the total.

10
recruiting participants now
67%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: PPD Development
Phase 12Phase 24Phase 31

Active & Recent Trials

15 total, page 1 of 1

RECRUITING 4,000 participants

The APS Phenotyping Study

Vanderbilt University Medical Center

NCT06521502

RECRUITING Phase 3 970 participants

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

Direct Biologics

NCT05354141

RECRUITING NA 800 participants

Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.

The University of Texas Medical Branch, Galveston

NCT06737432

RECRUITING NA 740 participants

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

Unity Health Toronto

NCT03963622

RECRUITING Phase 2 600 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

PPD Development

NCT06703073

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

PPD Development

NCT06701656

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

PPD Development

NCT06701682

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

PPD Development

NCT06701669

RECRUITING NA 180 participants

Clinical Decision Support Tool in PARDS Pilot Study

Children's Hospital Los Angeles

NCT04068012

RECRUITING 50 participants

Ventilatory Parameters in Predicting Outcomes in ARDS Patients

CentraCare

NCT06400095

COMPLETED 89 participants

Retrospective Postoperative ARDS Study at Vanderbilt University

Vanderbilt University

NCT00656071

COMPLETED Phase 1 72 participants

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Apellis Pharmaceuticals

NCT04402060

COMPLETED NA 58 participants

Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

University of Vermont

NCT04067622

COMPLETED Phase 1 45 participants

REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia

Cellenkos

NCT04468971

COMPLETED NA 13 participants

Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS

Christiana Care Health Services

NCT01272882

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the ARDS Trial Landscape

15 indexed ARDS studies · 10 recruiting (67%).

Phase mix: 1 late (III/IV) vs 6 early (I/II).

Top sponsor: PPD Development (4 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for ARDS?

PlainTrial tracks 15 US clinical trials for ARDS, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for ARDS?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.