Direct Biologics
Direct Biologics sponsors 7 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 1 completed. 1 of these trials are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Perianal Fistula Due to Crohn's Disease, with 1 trials.
Trial Pipeline
7 total, page 1 of 1
DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease
NCT06918808
Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
NCT05354141
DB-3Q for the Treatment of Medically Refractory Crohn's Disease
NCT07625293
Study of ExoFlo for the Treatment of Perianal Fistulas
NCT05836883
Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease
NCT05130983
Study of ExoFlo for the Treatment of Medically Refractory Ulcerative Colitis
NCT05176366
Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS
NCT04493242
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
| Phase 3 | 1 |
Therapeutic Areas
What the Pipeline for Direct Biologics Shows
According to the ClinicalTrials.gov registry, Direct Biologics is linked to 7 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 29% of the sponsor's indexed portfolio, and 1 are already marked complete, representing roughly 14% of the total.
The phase mix for Direct Biologics reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 6 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Direct Biologics is Perianal Fistula Due to Crohn's Disease with 1 linked trial, and 2 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.