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NCT03963622 · ClinicalTrials.gov registry record · NA
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
A NA study of ARDS, sponsored by Unity Health Toronto.
- Recruiting
- Registry status
- NA
- Development phase
- 740
- Enrollment target
- 20
- Study locations
NCT03963622 is a NA study of ARDS that is actively recruiting participants, run by Unity Health Toronto. The registered enrollment target is 740 participants, above the 534-participant average among 14 other ARDS trials with a reported enrollment target (39% higher). The trial reports 20 study locations across 2 states.
The verdict
NCT03963622, a NA study of ARDS, is actively recruiting participants, sponsored by Unity Health Toronto.
- RECRUITING
- Registry status
- NA
- Development phase
- 740 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol implemented in two different study populations (COVID-19 and non-COVID-19 patients). As per a typical basket trial design, the operational structure of both the COVID-19 substudy (CAVIARDS-19) and non-COVID-19 substudy (CAVIARDS-all) is shared (recruitment, procedures, data collection, analysis, management, etc.).
Conditions Studied
Interventions
- OTHER Respiratory Mechanics
- OTHER Standard Ventilation Strategy
Study Locations (20)
Other
- Centro de Educación Médica e Investigaciones Clínicas Dr Norberto Quirno (CEMIC) - Buenos Aires
- Complejo Médico Policía Federal Argentina Churruca Visca - Buenos Aires
- Hospital Británico de Buenos Aires - Buenos Aires
- Sanatorio Anchorena Recoleta - Buenos Aires
- Sanatorio Mater Dei - Buenos Aires
- Sanatorio Anchorena San Martín - San Martín
- St. Michael's Hospital - Toronto
- Toronto General Hospital - Toronto
- Toronto Western Hospital - Toronto
- Pontificia Universidad Católica de Chile - Santiago
- CHU Amiens-Picardie - Amiens
- Centre hospitalier universitaire d'Angers - Angers
- CH Victor Dupouy - Argenteuil
- CH de Beauvais - Beauvais
- CHU Bordeaux - Haut Leveque - Bordeaux
- Hopital de la Cavale Blanche - CHRU Brest - Brest
- CH de Cholet - Cholet
- Hopital Intercommunal de Creteil - Créteil
- CHU Grenoble-Alpes - Grenoble
New York
- New York University Grossman School of Medicine - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 740 participants |
| Start Date | 2020-11-23 |
| Est. Completion | 2026-09 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03963622
The ClinicalTrials.gov registry entry for NCT03963622 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 740 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 534-participant average among 14 other ARDS trials with a reported enrollment target (39% higher). The listed sponsor is Unity Health Toronto, which has 12 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with ARDS appearing as the primary indexed condition, and to 2 interventions - of which Respiratory Mechanics is the first listed.
NCT03963622 reports 20 study locations spanning 2 distinct geographic areas - top geographies include Other, New York.
Frequently Asked Questions
What is clinical trial NCT03963622 about?
NCT03963622 is a clinical study titled "Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)". This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The ...
What is the current status of trial NCT03963622?
This trial is currently recruiting. It is a NA study. The enrollment target is 740 participants. The study started on 2020-11-23. Estimated completion is 2026-09.
What conditions does trial NCT03963622 study?
This clinical trial studies the following conditions: ARDS.
What interventions are being tested in trial NCT03963622?
The interventions under investigation include: Respiratory Mechanics (OTHER), Standard Ventilation Strategy (OTHER).
Who is sponsoring clinical trial NCT03963622?
This trial is sponsored by Unity Health Toronto, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03963622 being conducted?
This trial has 20 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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