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Pathogenetic Basis of Aortopathy and Aortic Valve Disease
NCT03440697 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.
Conditions Studied
Study Locations (2)
Georgia
- Childrens Healthcare of Atlanta — Atlanta
Indiana
- IU School of Medicine — Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,000 participants |
| Start Date | 2015-12-10 |
| Est. Completion | 2030-12-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03440697
The ClinicalTrials.gov registry entry for NCT03440697 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 3,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,283 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Aortic Valve Disease appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03440697 reports 2 study locations spanning 2 distinct geographic areas — top geographies include Georgia, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03440697 about?
NCT03440697 is a clinical study titled "Pathogenetic Basis of Aortopathy and Aortic Valve Disease". The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disea...
What is the current status of trial NCT03440697?
This trial is currently active not recruiting. The enrollment target is 3,000 participants. The study started on 2015-12-10. Estimated completion is 2030-12-31.
What conditions does trial NCT03440697 study?
This clinical trial studies the following conditions: Aortic Valve Disease, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, Thoracic Aortic Disease, Aortopathies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT03440697?
This trial is sponsored by Yale University, which has 1,283 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03440697 being conducted?
This trial has 2 study locations across Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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