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NCT04149600 · ClinicalTrials.gov registry record
Identification of Genetic Causes of Calcific Aortic Valve Disease
A clinical trial of Aortic Valve Disease and Aortic Aneurysm, sponsored by Beth Israel Deaconess Medical Center.
- Active
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT04149600: Active study of Aortic Valve Disease and Aortic Aneurysm, sponsored by Beth Israel Deaconess Medical Center.
NCT04149600 is a study of Aortic Valve Disease and Aortic Aneurysm that is active but no longer recruiting, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 1,000 participants, below the 18,550-participant average among 15 other Aortic Valve Disease trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04149600, a study of Aortic Valve Disease and Aortic Aneurysm, is active but no longer recruiting, sponsored by Beth Israel Deaconess Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
Primary Outcome
We will take a portion of the aortic valve and/or aortic tissue that is routinely excised for aortic valve or aortic replacement for expression analyses and generation of fibroblast cell lines. In collaboration with the Department of Pathology, we have established methods to take sufficient "normal" and abnormal tissue while allowing formal routine pathological evaluation. All tissue samples for expression analysis will be transported in iced RNALater and later frozen in a -80°C research freeze
Conditions Studied
Interventions
- PROCEDURE Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2018-09-25 |
| Est. Completion | 2027-06-30 |
What the registry record for NCT04149600 still lists
NCT04149600 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, below the 18,550-participant average among 15 other Aortic Valve Disease trials with a reported enrollment target (95% lower).
The record links to 9 conditions, with Aortic Valve Disease appearing as the primary indexed condition, and to 1 intervention - of which Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study. is the first listed.
NCT04149600 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04149600 about?
NCT04149600 is a clinical study titled "Identification of Genetic Causes of Calcific Aortic Valve Disease". This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
What is the current status of trial NCT04149600?
This trial is currently active not recruiting. The enrollment target is 1,000 participants. The study started on 2018-09-25. Estimated completion is 2027-06-30.
What conditions does trial NCT04149600 study?
This clinical trial studies the following conditions: Aortic Valve Disease, Aortic Aneurysm, Aortic Valve Insufficiency, Aortic Diseases, Aortic Valve Disease Mixed.
What interventions are being tested in trial NCT04149600?
The interventions under investigation include: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study. (PROCEDURE).
Who is sponsoring clinical trial NCT04149600?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04149600 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04149600's enrollment target sits among peer trials
1,000 3rd of 15 higher than 13 of 15 other Aortic Valve Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aortic Valve Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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