Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer
NCT00707889 · View on ClinicalTrials.gov ↗
Study Summary
To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.
Conditions Studied
Interventions
- DRUG bevacizumab
- DRUG oxaliplatin
- DRUG fluorouracil
- DRUG folinic acid
- DRUG ABT-869
Study Locations (20)
Other
- Site Reference ID/Investigator# 18581 — Bedford Park
- Site Reference ID/Investigator# 23443 — Herston
- Site Reference ID/Investigator# 18023 — Bonheiden
- Site Reference ID/Investigator# 23646 — Brussels
- Site Reference ID/Investigator# 18026 — Leuven
- Site Reference ID/Investigator# 18022 — Roeselare
- Site Reference ID/Investigator# 26662 — Jaú
- Site Reference ID/Investigator# 24245 — Porto Alegre
- Site Reference ID/Investigator# 23265 — Barrie
- Site Reference ID/Investigator# 21083 — Edmonton
- Site Reference ID/Investigator# 22465 — Ottawa
- Site Reference ID/Investigator# 22141 — Náchod
- Site Reference ID/Investigator# 22289 — Heraklion
- Site Reference ID/Investigator# 22286 — Thessaloniki
- Site Reference ID/Investigator# 22287 — Thessaloniki
- Site Reference ID/Investigator# 20281 — Wellington South
- Site Reference ID/Investigator# 20141 — Olsztyn
North Carolina
- Site Reference ID/Investigator# 11341 — Chapel Hill
Pennsylvania
- Site Reference ID/Investigator# 20801 — Philadelphia
Tennessee
- Site Reference ID/Investigator# 8360 — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 159 participants |
| Start Date | 2008-10 |
| Est. Completion | 2012-05 |
| Phase | Phase 2 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00707889
The ClinicalTrials.gov registry entry for NCT00707889 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 159 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie (prior sponsor, Abbott), which has 16 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Adenocarcinoma of the Rectum appearing as the primary indexed condition, and to 5 interventions — of which bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00707889 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Other, North Carolina, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00707889 about?
NCT00707889 is a clinical study titled "Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer". To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.
What is the current status of trial NCT00707889?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 159 participants. The study started on 2008-10. Estimated completion is 2012-05.
What conditions does trial NCT00707889 study?
This clinical trial studies the following conditions: Adenocarcinoma of the Rectum, Advanced Colorectal Cancer, Adenocarcinoma of the Colon. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00707889?
The interventions under investigation include: bevacizumab (DRUG), oxaliplatin (DRUG), fluorouracil (DRUG), folinic acid (DRUG), ABT-869 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00707889?
This trial is sponsored by AbbVie (prior sponsor, Abbott), which has 16 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00707889 being conducted?
This trial has 20 study locations across North Carolina, Pennsylvania, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.