Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06778434 · ClinicalTrials.gov registry record · Phase 2
The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans
A Phase 2 study of Actinic Keratosis and Imipramine, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT06778434: Recruiting Phase 2 study of Actinic Keratosis and Imipramine, sponsored by VA Office of Research and Development.
NCT06778434 is a Phase 2 study of Actinic Keratosis and Imipramine that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 48 participants, below the 186-participant average among 16 other Actinic Keratosis trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06778434, a Phase 2 study of Actinic Keratosis and Imipramine, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to test the use of topical imipramine in combination with topical photodynamic therapy's (PDT) effect on the effectiveness and pain immunosuppression following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis or "AK") on their skin. These are both FDA-approved medications, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using mice that suggest imipramine might reduce immune system suppression by PDT thus allowing it to work better. Subjects whose provider has decided that they may benefit from PDT to treat their skin due to many AK precancerous lesions will be recruited for this study. Please note that the PDT itself is not experimental, only the imipramine treatment to the skin. There is a separate informed consent for the PDT.
Primary Outcome
Size of skin reactions from baseline values will be obtained following PDT + vehicle/imipramine using calipers.
Conditions Studied
Interventions
- DRUG Imipramine
- OTHER Control Vehicle
Study Locations (1)
Ohio
- Dayton VA Medical Center, Dayton, OH - Dayton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-04-01 |
| Est. Completion | 2029-03-30 |
| Phase | Phase 2 |
What NCT06778434 shows while recruiting
NCT06778434 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 186-participant average among 16 other Actinic Keratosis trials with a reported enrollment target (74% lower).
The record links to 3 conditions, with Actinic Keratosis appearing as the primary indexed condition, and to 2 interventions - of which Imipramine is the first listed.
NCT06778434 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06778434 about?
NCT06778434 is a clinical study titled "The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans". The purpose of this study is to test the use of topical imipramine in combination with topical photodynamic therapy's (PDT) effect on the effectiveness and pain immunosuppression following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic kera...
What is the current status of trial NCT06778434?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2025-04-01. Estimated completion is 2029-03-30.
What conditions does trial NCT06778434 study?
This clinical trial studies the following conditions: Actinic Keratosis, Imipramine, Photodynamic Therapy.
What interventions are being tested in trial NCT06778434?
The interventions under investigation include: Imipramine (DRUG), Control Vehicle (OTHER).
Who is sponsoring clinical trial NCT06778434?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06778434 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Actinic Keratosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06778434's enrollment target sits among peer trials
48 13th of 16 higher than 4 of 16 other Actinic Keratosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Actinic Keratosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients
ACTIVE NOT RECRUITING · Phase 2
-
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
RECRUITING · Phase 1
-
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp
ACTIVE NOT RECRUITING · Phase 3
-
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities
ACTIVE NOT RECRUITING · Phase 3
-
Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp
COMPLETED · Phase 3
-
A Long Term Follow up Study of Patients Who Have Completed the PEP005-016 or PEP005-025 Studies
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01765777 · 48 participants · NA
Efficacy of Osteopathic Manipulative Medicine (OMM) and Phototherapy for Patients With Chronic Lower Back Pain
- NCT03073343 · 48 participants · NA
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
- NCT03431064 · 48 participants
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
- NCT03514602 · 48 participants · NA
Maternal Smoking Cessation and Pediatric Obesity Prevention
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI