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NCT05688904 · ClinicalTrials.gov registry record · Phase 1
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
A Phase 1 study of Actinic Keratosis and Imipramine, sponsored by Wright State University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT05688904 is a Phase 1 study of Actinic Keratosis and Imipramine that is actively recruiting participants, run by Wright State University. The registered enrollment target is 24 participants, below the 187-participant average among 16 other Actinic Keratosis trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05688904, a Phase 1 study of Actinic Keratosis and Imipramine, is actively recruiting participants, sponsored by Wright State University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.
Conditions Studied
Interventions
- DRUG Imipramine
- OTHER Vehicle
Study Locations (1)
Ohio
- Wright State Physicians - Fairborn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2023-01-19 |
| Est. Completion | 2028-03 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05688904
The ClinicalTrials.gov registry entry for NCT05688904 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 187-participant average among 16 other Actinic Keratosis trials with a reported enrollment target (87% lower). The listed sponsor is Wright State University, which has 32 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Actinic Keratosis appearing as the primary indexed condition, and to 2 interventions - of which Imipramine is the first listed.
NCT05688904 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT05688904 about?
NCT05688904 is a clinical study titled "The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy". The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both...
What is the current status of trial NCT05688904?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2023-01-19. Estimated completion is 2028-03.
What conditions does trial NCT05688904 study?
This clinical trial studies the following conditions: Actinic Keratosis, Imipramine, Photodynamic Therapy.
What interventions are being tested in trial NCT05688904?
The interventions under investigation include: Imipramine (DRUG), Vehicle (OTHER).
Who is sponsoring clinical trial NCT05688904?
This trial is sponsored by Wright State University, which has 32 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05688904 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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