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ClinicalTrials.gov 10 recruiting now official registry

CRC clinical trials

10 of 16 indexed CRC trials are currently recruiting.

16 US clinical trials · 10 currently recruiting

CRC is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is A2 Biotherapeutics, running 3 of these trials.

The research picture

CRC has 16 registered US clinical trials, 10 of them open to new participants right now, about 63% of the total.

10
recruiting participants now
63%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: A2 Biotherapeutics
Phase 112Phase 22

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 1 1,130 participants

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Revolution Medicines

NCT06445062

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 1 474 participants

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06051695

RECRUITING Phase 1 370 participants

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Revolution Medicines

NCT07397338

RECRUITING Phase 1 250 participants

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

Tubulis

NCT06657222

RECRUITING Phase 1 240 participants

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06682793

RECRUITING Phase 1 232 participants

A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors

SparX Biotech(Jiangsu) Co.

NCT06259552

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING Phase 2 97 participants

Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer

Virginia Commonwealth University

NCT06728072

RECRUITING Phase 1 80 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Cartography Biosciences

NCT07321106

ACTIVE NOT RECRUITING Phase 1 180 participants

Study to Evaluate D-1553 in Subjects With Solid Tumors

InventisBio Co.

NCT04585035

ACTIVE NOT RECRUITING Phase 2 113 participants

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

Cardiff Oncology

NCT06106308

ACTIVE NOT RECRUITING Phase 1 12 participants

Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy

University of California, Irvine

NCT04868773

COMPLETED Phase 1 52 participants

Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma

Jennerex Biotherapeutics

NCT01394939

COMPLETED NA 30 participants

Engaging Black Men in Colorectal Cancer Screening

Virginia Commonwealth University

NCT05980182

COMPLETED Phase 1 29 participants

JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Jacobio Pharmaceuticals Co.

NCT05002270

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the CRC Trial Landscape

16 indexed CRC studies · 10 recruiting (63%).

Phase mix: 0 late (III/IV) vs 14 early (I/II).

Top sponsor: A2 Biotherapeutics (3 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for CRC?

PlainTrial tracks 16 US clinical trials for CRC, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for CRC?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.