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ClinicalTrials.gov 15 recruiting now official registry

Colorectal Cancer (CRC) clinical trials

15 of 20 indexed Colorectal Cancer (CRC) trials are currently recruiting.

20 US clinical trials · 15 currently recruiting

Colorectal Cancer (CRC) is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is Revolution Medicines, running 5 of these trials.

The research picture

Colorectal Cancer (CRC) has 20 registered US clinical trials, 15 of them open to new participants right now, about 75% of the total.

15
recruiting participants now
75%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: Revolution Medicines
Phase 115Phase 23Phase 31

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 1 1,314 participants

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Exelixis

NCT05176483

RECRUITING 1,300 participants

Collection of Samples USOPTIVAL Study

Universal Diagnostics

NCT04792684

RECRUITING Phase 1 754 participants

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Revolution Medicines

NCT05379985

RECRUITING Phase 1 604 participants

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Revolution Medicines

NCT06040541

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 2 400 participants

Evaluation of Gixam's Performance in a FIT Negative Population

Jubaan

NCT06612281

RECRUITING Phase 1 370 participants

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Revolution Medicines

NCT07397338

RECRUITING Phase 1 358 participants

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

GI Innovation

NCT05824975

RECRUITING Phase 1 300 participants

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

Kura Oncology

NCT06026410

RECRUITING Phase 1 252 participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

Bristol-Myers Squibb

NCT07223047

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING Phase 1 126 participants

Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma

HonorHealth Research Institute

NCT07463599

RECRUITING Phase 1 90 participants

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

Portage Biotech

NCT04969315

RECRUITING Phase 1 80 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Cartography Biosciences

NCT07321106

RECRUITING Phase 2 60 participants

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)

SCRI Development Innovations

NCT07011576

ACTIVE NOT RECRUITING Phase 1 350 participants

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

Genmab

NCT04083599

ACTIVE NOT RECRUITING Phase 1 222 participants

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Revolution Medicines

NCT05462717

ACTIVE NOT RECRUITING Phase 3 160 participants

Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation

Amgen

NCT05198934

ACTIVE NOT RECRUITING Phase 2 10 participants

An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib

Incyte Corporation

NCT02955940

COMPLETED Phase 1 149 participants

A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

Incyte Corporation

NCT03314935

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 3
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Colorectal Cancer (CRC) Trial Landscape

20 indexed Colorectal Cancer (CRC) studies · 15 recruiting (75%).

Phase mix: 1 late (III/IV) vs 18 early (I/II).

Top sponsor: Revolution Medicines (5 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Colorectal Cancer (CRC)?

PlainTrial tracks 20 US clinical trials for Colorectal Cancer (CRC), of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Colorectal Cancer (CRC)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.