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NCT01940757 · ClinicalTrials.gov registry record · Phase 1
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
A Phase 1 study of Hookworm Infection, sponsored by Baylor College of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
- 1
- Study location
NCT01940757 is a Phase 1 study of Hookworm Infection that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 35 participants. The trial reports 1 study location across 1 state.
The verdict
NCT01940757, a Phase 1 study of Hookworm Infection, is actively recruiting participants, sponsored by Baylor College of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookworm vaccine, followed by challenging them with the investigational product, Necator americanus Larval Inoculum to assess the effect of vaccination on infection. The first proposed study will be a feasibility study that will consist of administering different doses of the Necator americanus Larval Inoculum to healthy adult volunteers to determine the optimal dose (i.e., number of infectious larvae) that is safe, well-tolerated and results in consistent infection.
Conditions Studied
Interventions
- BIOLOGICAL Necator americanus Hookworm Larvae
Study Locations (1)
District of Columbia
- George Washington University Medical Faculty Associates - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2015-01 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01940757
The ClinicalTrials.gov registry entry for NCT01940757 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 35 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Hookworm Infection appearing as the primary indexed condition, and to 1 intervention - of which Necator americanus Hookworm Larvae is the first listed.
NCT01940757 reports 1 study location spanning 1 distinct geographic area - top geographies include District of Columbia.
Frequently Asked Questions
What is clinical trial NCT01940757 about?
NCT01940757 is a clinical study titled "Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae". An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookwor...
What is the current status of trial NCT01940757?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2015-01. Estimated completion is 2026-12.
What conditions does trial NCT01940757 study?
This clinical trial studies the following conditions: Hookworm Infection.
What interventions are being tested in trial NCT01940757?
The interventions under investigation include: Necator americanus Hookworm Larvae (BIOLOGICAL).
Who is sponsoring clinical trial NCT01940757?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01940757 being conducted?
This trial has 1 study location across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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