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NCT01940757 · ClinicalTrials.gov registry record · Phase 1
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
A Phase 1 study of Hookworm Infection, sponsored by Baylor College of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
- 1
- Study location
NCT01940757: Recruiting Phase 1 study of Hookworm Infection, sponsored by Baylor College of Medicine.
NCT01940757 is a Phase 1 study of Hookworm Infection that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 35 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01940757, a Phase 1 study of Hookworm Infection, is actively recruiting participants, sponsored by Baylor College of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookworm vaccine, followed by challenging them with the investigational product, Necator americanus Larval Inoculum to assess the effect of vaccination on infection. The first proposed study will be a feasibility study that will consist of administering different doses of the Necator americanus Larval Inoculum to healthy adult volunteers to determine the optimal dose (i.e., number of infectious larvae) that is safe, well-tolerated and results in consistent infection.
Primary Outcome
Frequency of study product-related adverse events, graded by severity, for different doses of N. americanus Larval Inoculum.
Conditions Studied
Interventions
- BIOLOGICAL Necator americanus Hookworm Larvae
Study Locations (1)
District of Columbia
- George Washington University Medical Faculty Associates - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2015-01 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
What NCT01940757 shows while recruiting
NCT01940757 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower).
The record links to 1 condition, with Hookworm Infection appearing as the primary indexed condition, and to 1 intervention - of which Necator americanus Hookworm Larvae is the first listed.
NCT01940757 reports a single indexed study location in District of Columbia.
Frequently Asked Questions
What is clinical trial NCT01940757 about?
NCT01940757 is a clinical study titled "Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae". An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookwor...
What is the current status of trial NCT01940757?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2015-01. Estimated completion is 2026-12.
What conditions does trial NCT01940757 study?
This clinical trial studies the following conditions: Hookworm Infection.
What interventions are being tested in trial NCT01940757?
The interventions under investigation include: Necator americanus Hookworm Larvae (BIOLOGICAL).
Who is sponsoring clinical trial NCT01940757?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01940757 being conducted?
This trial has 1 study location across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hookworm Infection
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01940757's enrollment target sits among peer trials
35 1259th of 2000 higher than 728 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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