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NCT03115632 · ClinicalTrials.gov registry record
Contributing Factors in the Pathobiology of Airway Remodeling in Obesity
A clinical trial of Obesity and Asthma, sponsored by Duke University.
- Completed
- Registry status
- 31
- Enrollment target
- 2
- Study locations
NCT03115632: Completed study of Obesity and Asthma, sponsored by Duke University.
NCT03115632 is a study of Obesity and Asthma that has completed, run by Duke University. The registered enrollment target is 31 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (96% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03115632, a study of Obesity and Asthma, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 31 participants
- Enrollment target
- 2
- Study locations
Study Summary
There are two aims for this study. The purpose of this study is to determine the effects of body weight and hormones on airway fibrosis (scarring) and lung function in obese \& lean asthma subjects compared to obese \& lean non-asthma subjects (Aim 1). And in obese subjects with asthma undergoing bariatric surgery compared to obese non-asthma subjects undergoing bariatric surgery (Aim 2).
Primary Outcome
Obese asthmatics compared to lean asthmatics, obese non-asthmatics and lean non-asthmatics: A univariate linear model will be constructed to measure the effect of leptin or GLP-1 (glucagon-like peptide-1) on airway fibrosis, as measured by the ratio of Masson's trichrome-stained area to non-stained area in the sub-mucosal region of airway biopsy tissue.
Conditions Studied
Study Locations (2)
North Carolina
- Duke Metabolic and Weight Loss Surgery Center - Durham
- Duke Asthma Allergy and Airway Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2018-04-09 |
| Est. Completion | 2023-06-27 |
What the finished NCT03115632 record still lists
NCT03115632 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (96% lower).
The record links to 4 conditions, with Obesity appearing as the primary indexed condition, and to 0 interventions.
NCT03115632 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT03115632 about?
NCT03115632 is a clinical study titled "Contributing Factors in the Pathobiology of Airway Remodeling in Obesity". There are two aims for this study. The purpose of this study is to determine the effects of body weight and hormones on airway fibrosis (scarring) and lung function in obese \& lean asthma subjects compared to obese \& lean non-asthma subjects (Aim 1). And in obese subjects with asthma undergoing ba...
What is the current status of trial NCT03115632?
This trial is currently completed. The enrollment target is 31 participants. The study started on 2018-04-09. Estimated completion is 2023-06-27.
What conditions does trial NCT03115632 study?
This clinical trial studies the following conditions: Obesity, Asthma, Bariatric Surgery Candidate, Obesity, Morbid.
Who is sponsoring clinical trial NCT03115632?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03115632 being conducted?
This trial has 2 study locations across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03115632's enrollment target sits among peer trials
31 847th of 1053 higher than 204 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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