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NCT03128996 · ClinicalTrials.gov registry record · Phase 1
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
A Phase 1 study of Hemoglobinopathies and Metabolic Disorders, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 4
- Study locations
NCT03128996: Recruiting Phase 1 study of Hemoglobinopathies and Metabolic Disorders, sponsored by Washington University School of Medicine.
NCT03128996 is a Phase 1 study of Hemoglobinopathies and Metabolic Disorders that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 29 participants, below the 1,802-participant average among 17 other Hemoglobinopathies trials with a reported enrollment target (98% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03128996, a Phase 1 study of Hemoglobinopathies and Metabolic Disorders, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 4
- Study locations
Study Summary
This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure.
Primary Outcome
as measured by chimerism
Conditions Studied
Interventions
- DRUG RIC regimen
- DRUG GVHD prophylaxis regimen
Study Locations (4)
Connecticut
- Yale School of Medicine - New Haven
Delaware
- Nemours Children's Health - Wilmington
Michigan
- Helen DeVos Children's Hospital - Grand Rapids
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2017-03-20 |
| Est. Completion | 2033-04 |
| Phase | Phase 1 |
What NCT03128996 shows while recruiting
NCT03128996 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 1,802-participant average among 17 other Hemoglobinopathies trials with a reported enrollment target (98% lower).
The record links to 6 conditions, with Hemoglobinopathies appearing as the primary indexed condition, and to 2 interventions - of which RIC regimen is the first listed.
NCT03128996 reports a single indexed study location in Connecticut, Delaware, Michigan.
Frequently Asked Questions
What is clinical trial NCT03128996 about?
NCT03128996 is a clinical study titled "Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders". This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure.
What is the current status of trial NCT03128996?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2017-03-20. Estimated completion is 2033-04.
What conditions does trial NCT03128996 study?
This clinical trial studies the following conditions: Hemoglobinopathies, Metabolic Disorders, Bone Marrow Failure Syndromes, Non-malignant Disorders, Severe Sickle Cell Disease.
What interventions are being tested in trial NCT03128996?
The interventions under investigation include: RIC regimen (DRUG), GVHD prophylaxis regimen (DRUG).
Who is sponsoring clinical trial NCT03128996?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03128996 being conducted?
This trial has 4 study locations across Connecticut, Delaware, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hemoglobinopathies
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03128996's enrollment target sits among peer trials
29 9th of 17 higher than 9 of 17 other Hemoglobinopathies trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hemoglobinopathies trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
RECRUITING · Phase 1
-
A Blood Stem Cell Transplant for Sickle Cell Disease
ACTIVE NOT RECRUITING · Phase 1
-
A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)
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EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)
ACTIVE NOT RECRUITING · Phase 1
-
Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders
COMPLETED · Phase 1
-
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
RECRUITING · NA
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