Vertex Pharmaceuticals Incorporated
Vertex Pharmaceuticals Incorporated sponsors 191 registered US clinical trials on ClinicalTrials.gov, 20 of them currently recruiting, and 144 completed. 67 of these trials are in Phase 3-4 (later-stage) and 119 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cystic Fibrosis, with 20 trials.
Trial Pipeline
191 total, page 4 of 4
A Study to Assess the Relative Bioavailability Three New Formulations of Telaprevir in Healthy Subjects
NCT01511432
Telaprevir, Peg-IFN-alfa-2a, and RBV in Treatment-Experienced Black/African American and Non-Black/African American Subjects With Genotype 1 Chronic Hepatitis C
NCT01467492
A Study to Treat Subjects With Telaprevir, Ribavirin, and Peginterferon Who Are Coinfected With HIV and Hepatitis C Virus (HCV)
NCT01467479
A Study to Evaluate the Efficacy and Safety of VX-765 in Subjects With Treatment-Resistant Partial Epilepsy
NCT01501383
Efficacy of a 12-Week Regimen of Telaprevir, Pegylated Interferon, and Ribavirin in Treatment-Naive and Prior Relapser Subjects With Interleukin28B (IL28B) CC Genotype
NCT01459913
Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation
NCT01262352
Drug-Drug Interaction Study Between Telaprevir and Buprenorphine
NCT01275599
Drug-Drug Interaction Study of VX-770 and VX-809 in Healthy Subjects
NCT01216046
Study of VX-809 Alone and in Combination With VX-770 in Cystic Fibrosis (CF) Patients Homozygous or Heterozygous for the F508del-CFTR Mutation
NCT01225211
Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D Mutation
NCT01161537
A Safety and Efficacy Study of the Combination of VX-222 and Telaprevir in Treatment-Naïve Subjects With Genotype 1 Chronic Hepatitis C Virus Infection
NCT01080222
Rollover Study of VX-770 in Cystic Fibrosis Subjects
NCT01117012
Study of VX-985 in Subjects With Chronic Hepatitis C
NCT01144936
Study of VX-770 on Desipramine
NCT01153542
A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid Arthritis
NCT01052194
Study of VX-770 on Midazolam and Rosiglitazone and the Effect of Fluconazole on VX-770
NCT01060566
A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
NCT01038167
Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy
NCT01048255
Study of VX-770 and Rifampin in Healthy Male Subjects
NCT01018368
Safety and Efficacy of Telaprevir in Combination With Peginterferon Alfa-2a and Ribavirin in Subjects Co-Infected With Hepatitis C Virus (HCV) and HIV
NCT00983853
Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation
NCT00953706
Study of Ivacaftor in Cystic Fibrosis Subjects Aged 6 to 11 Years With the G551D Mutation
NCT00909727
Virology Follow up Study in Subjects Previously Treated With Telaprevir
NCT00916474
Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation
NCT00909532
Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection
NCT00911963
Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation
NCT00865904
A Study Evaluating 24-Week and 48-Week Telaprevir-Based Regimen in Treatment Naïve Subjects With Genotype 1 Chronic Hepatitis C Who Achieve an Extended Rapid Viral Response
NCT00758043
Single and Multiple Dose Escalation Study of VX-509 in Healthy Subjects
NCT00789126
A Phase 3 Study of Telaprevir in Combination With Pegasys® and Copegus® in Treatment-Naive Subjects With Genotype 1 Hepatitis C Virus (HCV)
NCT00627926
Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection
NCT00623649
A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy
NCT00535847
Study of Telaprevir in Subjects With Hepatic Impairment
NCT00509210
AVN944 in Combination With Gemcitabine for the Treatment of Pancreatic Cancer
NCT00493441
Safety Study of Ivacaftor in Subjects With Cystic Fibrosis
NCT00457821
A Study of Telaprevir (VX-950), Pegasys and Copegus in Hepatitis C (PROVE3)
NCT00420784
Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis C
NCT00336479
Trial of AVN-944 in Patients With Advanced Hematologic Malignancies
NCT00273936
Phase 2 Study of VX-950, Pegasys and Copegus in Hepatitis C
NCT00262483
A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries
NCT00500812
Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C
NCT00088504
VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer
NCT00003847
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 62 |
| Phase 2 | 57 |
| Phase 3 | 62 |
| Phase 4 | 5 |
What the Pipeline for Vertex Pharmaceuticals Incorporated Shows
According to the ClinicalTrials.gov registry, Vertex Pharmaceuticals Incorporated is linked to 191 US clinical trials across every stage of research activity. Of those, 20 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 144 are already marked complete, representing roughly 75% of the total.
The phase mix for Vertex Pharmaceuticals Incorporated reports 67 late-stage studies (Phase 3 and Phase 4 combined) and 119 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Vertex Pharmaceuticals Incorporated is Cystic Fibrosis with 20 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.