Vertex Pharmaceuticals Incorporated

191 total trials 20 currently recruiting 144 completed

Vertex Pharmaceuticals Incorporated sponsors 191 registered US clinical trials on ClinicalTrials.gov, 20 of them currently recruiting, and 144 completed. 67 of these trials are in Phase 3-4 (later-stage) and 119 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cystic Fibrosis, with 20 trials.

Trial Pipeline

191 total, page 4 of 4

COMPLETED Phase 1

A Study to Assess the Relative Bioavailability Three New Formulations of Telaprevir in Healthy Subjects

NCT01511432

TERMINATED Phase 4

Telaprevir, Peg-IFN-alfa-2a, and RBV in Treatment-Experienced Black/African American and Non-Black/African American Subjects With Genotype 1 Chronic Hepatitis C

NCT01467492

TERMINATED Phase 3

A Study to Treat Subjects With Telaprevir, Ribavirin, and Peginterferon Who Are Coinfected With HIV and Hepatitis C Virus (HCV)

NCT01467479

TERMINATED Phase 2

A Study to Evaluate the Efficacy and Safety of VX-765 in Subjects With Treatment-Resistant Partial Epilepsy

NCT01501383

TERMINATED Phase 3

Efficacy of a 12-Week Regimen of Telaprevir, Pegylated Interferon, and Ribavirin in Treatment-Naive and Prior Relapser Subjects With Interleukin28B (IL28B) CC Genotype

NCT01459913

COMPLETED Phase 2

Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation

NCT01262352

COMPLETED Phase 1

Drug-Drug Interaction Study Between Telaprevir and Buprenorphine

NCT01275599

COMPLETED Phase 1

Drug-Drug Interaction Study of VX-770 and VX-809 in Healthy Subjects

NCT01216046

COMPLETED Phase 2

Study of VX-809 Alone and in Combination With VX-770 in Cystic Fibrosis (CF) Patients Homozygous or Heterozygous for the F508del-CFTR Mutation

NCT01225211

COMPLETED Phase 2

Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D Mutation

NCT01161537

TERMINATED Phase 2

A Safety and Efficacy Study of the Combination of VX-222 and Telaprevir in Treatment-Naïve Subjects With Genotype 1 Chronic Hepatitis C Virus Infection

NCT01080222

COMPLETED Phase 3

Rollover Study of VX-770 in Cystic Fibrosis Subjects

NCT01117012

COMPLETED Phase 1

Study of VX-985 in Subjects With Chronic Hepatitis C

NCT01144936

COMPLETED Phase 1

Study of VX-770 on Desipramine

NCT01153542

COMPLETED Phase 2

A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid Arthritis

NCT01052194

COMPLETED Phase 1

Study of VX-770 on Midazolam and Rosiglitazone and the Effect of Fluconazole on VX-770

NCT01060566

COMPLETED Phase 1

A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults

NCT01038167

COMPLETED Phase 2

Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy

NCT01048255

COMPLETED Phase 1

Study of VX-770 and Rifampin in Healthy Male Subjects

NCT01018368

COMPLETED Phase 2

Safety and Efficacy of Telaprevir in Combination With Peginterferon Alfa-2a and Ribavirin in Subjects Co-Infected With Hepatitis C Virus (HCV) and HIV

NCT00983853

TERMINATED Phase 2

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation

NCT00953706

COMPLETED Phase 3

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 6 to 11 Years With the G551D Mutation

NCT00909727

COMPLETED

Virology Follow up Study in Subjects Previously Treated With Telaprevir

NCT00916474

COMPLETED Phase 3

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation

NCT00909532

COMPLETED Phase 1

Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection

NCT00911963

COMPLETED Phase 2

Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation

NCT00865904

COMPLETED Phase 3

A Study Evaluating 24-Week and 48-Week Telaprevir-Based Regimen in Treatment Naïve Subjects With Genotype 1 Chronic Hepatitis C Who Achieve an Extended Rapid Viral Response

NCT00758043

COMPLETED Phase 1

Single and Multiple Dose Escalation Study of VX-509 in Healthy Subjects

NCT00789126

COMPLETED Phase 3

A Phase 3 Study of Telaprevir in Combination With Pegasys® and Copegus® in Treatment-Naive Subjects With Genotype 1 Hepatitis C Virus (HCV)

NCT00627926

COMPLETED Phase 1

Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

NCT00623649

COMPLETED Phase 2

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

NCT00535847

COMPLETED Phase 1

Study of Telaprevir in Subjects With Hepatic Impairment

NCT00509210

TERMINATED Phase 2

AVN944 in Combination With Gemcitabine for the Treatment of Pancreatic Cancer

NCT00493441

COMPLETED Phase 2

Safety Study of Ivacaftor in Subjects With Cystic Fibrosis

NCT00457821

COMPLETED Phase 2

A Study of Telaprevir (VX-950), Pegasys and Copegus in Hepatitis C (PROVE3)

NCT00420784

COMPLETED Phase 2

Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis C

NCT00336479

COMPLETED Phase 1

Trial of AVN-944 in Patients With Advanced Hematologic Malignancies

NCT00273936

COMPLETED Phase 2

Phase 2 Study of VX-950, Pegasys and Copegus in Hepatitis C

NCT00262483

COMPLETED Phase 1

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

NCT00500812

COMPLETED Phase 2

Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C

NCT00088504

TERMINATED Phase 2

VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer

NCT00003847

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What the Pipeline for Vertex Pharmaceuticals Incorporated Shows

According to the ClinicalTrials.gov registry, Vertex Pharmaceuticals Incorporated is linked to 191 US clinical trials across every stage of research activity. Of those, 20 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 144 are already marked complete, representing roughly 75% of the total.

The phase mix for Vertex Pharmaceuticals Incorporated reports 67 late-stage studies (Phase 3 and Phase 4 combined) and 119 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Vertex Pharmaceuticals Incorporated is Cystic Fibrosis with 20 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.