University of North Carolina, Chapel Hill

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, University of North Carolina, Chapel Hill sits in the top decile of US sponsors by registered trial count (#28 of 15,742 sponsors by registered trial count).

1,109 total trials 108 currently recruiting 881 completed early-phase tilt top decile by trial count

University of North Carolina, Chapel Hill: 1,109 sponsored US clinical trials, 108 recruiting.

University of North Carolina, Chapel Hill sponsors 1,109 registered US clinical trials on ClinicalTrials.gov, 108 of them currently recruiting, and 881 completed. 69 of these trials are in Phase 3-4 (later-stage) and 203 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 17 trials.

Top-decile sponsor footprint

University of North Carolina, Chapel Hill ranks in the top decile of sponsors by registered trial count (#28 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 69/100

881 of 962 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.6%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,109 total, page 12 of 23

TERMINATED Phase 4

MEtformin and Lorcaserin for WeighT Loss in Schizophrenia

NCT02796144

COMPLETED

Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors

NCT02885064

COMPLETED NA

Accelerated Invisalign Therapy in Conjunction With Acceledent Aura

NCT02868554

COMPLETED NA

Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants

NCT02872480

COMPLETED NA

A Volumetric Analysis of Soft and Hard Tissue Healing for Ridge Preservation and Socket Seal After Tooth Extraction

NCT02844569

COMPLETED NA

Feasibility Study of Retinal Screening Using the RetinaVue 100 Camera in Outpatient Dialysis Centers

NCT02823600

COMPLETED

VisR Ultrasound for Noninvasively Monitoring Renal Allograft Health

NCT03079882

COMPLETED NA

North Carolina Newborn Exome Sequencing for Universal Screening

NCT02826694

COMPLETED NA

Does a Mainstream Summer Camp Experience Improve Pediatric Kidney Patients' Physical Fitness and Self Concept?

NCT02803541

COMPLETED NA

A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.

NCT02781818

COMPLETED

Risk Factors for Microscopic Colitis

NCT02699333

COMPLETED NA

Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

NCT02747186

COMPLETED Phase 1

Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology

NCT02872467

TERMINATED NA

IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis

NCT02710903

COMPLETED NA

Application of a Novel Allergen-Specific Immune Signature Directed Approach to Dietary Elimination Therapy in Patients With Eosinophilic Esophagitis (IDiET)

NCT02722148

TERMINATED

Antiretroviral Localization in Gut-Associated Lymphoid Tissue and Lower Female Genital Tract Tissue of HIV+ Subjects

NCT02641444

COMPLETED

ARV Concentrations in Hair

NCT02768779

COMPLETED

Microbiome-mediated Weight, Anxiety, and Stress Dysregulation in Anorexia Nervosa

NCT03119272

COMPLETED

Conventional, Overdenture and Palateless Overdenture Oral Health Impact Comparison Study

NCT02731703

COMPLETED NA

Pain Coping Skills Training for African Americans With Osteoarthritis

NCT02560922

TERMINATED NA

Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials

NCT02532543

COMPLETED NA

Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

NCT02708433

COMPLETED NA

Triggered Palliative Care for Advanced Dementia

NCT02719938

COMPLETED NA

Walk With Ease Program For Patients With Systemic Lupus Erythematosus

NCT02631005

TERMINATED Phase 1

Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection

NCT02707900

COMPLETED NA

Tick-borne Illness and Clothing Study of Rhode Island

NCT02613585

COMPLETED NA

Testing the Efficacy of a Spousal Support Enhanced Weight Loss Program on Weight Loss Among African American Men

NCT02458053

COMPLETED Phase 1

Oxytocin Treatment of Opioid Dependence

NCT02548728

COMPLETED Phase 2

Contrast-enhanced Ultrasound of the Kidney

NCT02684435

COMPLETED Phase 4

Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?

NCT02972554

COMPLETED NA

Impact of an Oral Health Intervention

NCT03921632

COMPLETED NA

Technology Enhanced Behavioral Activation Treatment for Substance Use

NCT02707887

COMPLETED

To Determine the Validity of the ACT in an Adolescent Population With Persistent Asthma

NCT02662413

TERMINATED

Teriflunomide's Therapeutic Mechanisms of Action in Patients With Relapsing Remitting Multiple Sclerosis.

NCT02833714

COMPLETED

The Compartmental Biology of HIV in the Male Genital Tract

NCT02638493

COMPLETED NA

Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine

NCT02620683

TERMINATED NA

Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth

NCT02572570

COMPLETED Phase 2

Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD)

NCT02527798

COMPLETED Phase 2

Cathelicidin and Vitamin D: Impact on Populations At-Risk and With COPD

NCT02464059

COMPLETED NA

Evaluation of a Short Course of Gamma Tocopherol Supplementation in Adult Subjects

NCT02610829

COMPLETED

Self-Consent for PrEP Perspectives

NCT02801760

COMPLETED Phase 1

Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS

NCT02104505

COMPLETED

The Patient-Reported Outcomes Project of HCV-TARGET

NCT02601820

COMPLETED NA

Vibratory Stimuli, A Novel Rehabilitation Method for Preventing Post - Traumatic Knee Osteoarthritis

NCT02605876

COMPLETED Phase 4

Perimenopausal Effects of Estradiol on Reward Responsiveness

NCT02255175

COMPLETED

Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn

NCT02653157

COMPLETED NA

The KNEEhabilitation Study: Improving Disability in Individuals With Knee Osteoarthritis

NCT02634814

COMPLETED NA

The Listening Project at Reiss-Davis/Vista Del Mar Child and Family Services

NCT02398422

COMPLETED NA

Methods for Managing Intrusive Thoughts

NCT03416504

TERMINATED Phase 1

Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study

NCT02220426

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Phase Distribution

PhaseTrial count
Phase 1 111
Phase 2 92
Phase 3 13
Phase 4 56

What is open in the University of North Carolina, Chapel Hill pipeline

108 recruiting of 1,109 indexed (10% open); 881 completed (79%).

Phase mix: 69 late (III/IV) vs 203 early (I/II) (early-phase heavy).

Top condition: Obesity (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

University of North Carolina, Chapel Hill: open-pipeline peers nationwide

Peers matched on 1,109 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 8%10%12%14%16%18%20% Total trials Recruiting share University of North Carolina, Chapel HillUniversity of FloridaWake Forest University Health SciencesUniversity of Alabama at BirminghamNYU Langone HealthChildren's Hospitals and Clinics of MinnesotaCytokineticsSanofiOhio University
University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

University of North Carolina, Chapel Hill sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,109 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this University of North Carolina, Chapel Hill page

1,109 registered trials is a research-attention snapshot, not an endorsement of University of North Carolina, Chapel Hill or any single study.

  • 108 of University of North Carolina, Chapel Hill's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition University of North Carolina, Chapel Hill studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. University of North Carolina, Chapel Hill pipeline card: 1,109 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.