The Medicines Company

35 total trials 32 completed

The Medicines Company sponsors 35 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 32 completed. 24 of these trials are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Thrombosis, with 2 trials.

Trial Pipeline

35 total, page 1 of 1

COMPLETED Phase 3

Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol

NCT03399370

COMPLETED Phase 3

Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH)

NCT03397121

COMPLETED Phase 4

Safety of Either a Single or Two Intravenous Doses of Orbactiv in Participants With Acute Bacterial Skin and Skin Structure Infection

NCT02925416

COMPLETED Phase 2

A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)

NCT02963311

COMPLETED Phase 2

Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)

NCT02597127

COMPLETED Phase 4

A Study to Evaluate the Safety of a Single Intravenous (IV) Dose of Orbactiv (Oritavancin) in Participants on Chronic Warfarin Therapy Being Treated For Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

NCT02452918

COMPLETED Phase 1

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of a New Formulation of Oritavancin in Healthy Volunteers

NCT02471690

COMPLETED Phase 3

Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants

NCT02395653

COMPLETED Phase 2

Cangrelor to Clopidogrel or Prasugrel Transition Study

NCT01979445

TERMINATED Phase 3

ENDOvascular Interventions With AngioMAX: The ENDOMAX Trial

NCT01913483

COMPLETED Phase 2

Cangrelor Prasugrel Transition Study

NCT01852019

COMPLETED Phase 2

Cangrelor Ticagrelor Transition Study

NCT01766466

COMPLETED Phase 3

A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX)

NCT01156571

COMPLETED Phase 3

Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO)

NCT00803634

COMPLETED Phase 2

Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT)

NCT00799604

COMPLETED Phase 2

Maintenance of Platelet Inhibition With Cangrelor

NCT00767507

COMPLETED Phase 3

Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE)

NCT00666328

COMPLETED Phase 1

Assess the Effect of Cangrelor at the Therapeutic Dose and a Supratherapeutic Dose Level on the QT/QTc Interval in Healthy Volunteers

NCT00699504

COMPLETED Phase 3

Clevidipine in the Treatment of Patients With Severe Hypertension (VELOCITY)

NCT00369837

TERMINATED Phase 3

Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition.

NCT00385138

TERMINATED Phase 3

A Clinical Trial to Demonstrate the Efficacy of Cangrelor

NCT00305162

COMPLETED Phase 1

Pharmacokinetics/Pharmacodynamics (PK/PD) of Cangrelor

NCT00102674

COMPLETED Phase 3

Clevidipine in the Perioperative Treatment of Hypertension (ECLISPE-SNP)

NCT00093912

COMPLETED Phase 3

Clevidipine in the Postoperative Treatment of Hypertension (ECLIPSE-NIC)

NCT00093925

COMPLETED Phase 3

Angiomax in Patients With HIT/HITTS Type II Undergoing CPB

NCT00079508

COMPLETED Phase 3

Bivalirudin in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary PCI

NCT00093184

COMPLETED Phase 3

Comparing Angiomax to Heparin With Protamine in Patients Undergoing Cardiopulmonary Bypass (CPB)

NCT00079586

COMPLETED Phase 3

Clevidipine in the Perioperative Treatment of Hypertension (ECLIPSE-NTG)

NCT00093886

COMPLETED Phase 3

Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-1)

NCT00093249

COMPLETED Phase 3

Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-2)

NCT00093262

COMPLETED Phase 3

Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE)

NCT00073580

COMPLETED Phase 3

Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB

NCT00073593

COMPLETED Phase 3

Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS)

NCT00093158

COMPLETED Phase 2

Study Of Angiomax In Infants Under Six Months With Thrombosis

NCT00043277

COMPLETED Phase 3

Anticoagulant Therapy With Bivalirudin in the Performance of Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (AT BAT, First Inning)

NCT00043940

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 8
Phase 3 22
Phase 4 2

What the Pipeline for The Medicines Company Shows

According to the ClinicalTrials.gov registry, The Medicines Company is linked to 35 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 32 are already marked complete, representing roughly 91% of the total.

The phase mix for The Medicines Company reports 24 late-stage studies (Phase 3 and Phase 4 combined) and 11 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for The Medicines Company is Thrombosis with 2 linked trials, and 5 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.