Smith & Nephew

72 total trials 3 currently recruiting 39 completed

Smith & Nephew sponsors 72 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 39 completed. 4 of these trials are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Total Knee Arthroplasty, with 3 trials.

Trial Pipeline

72 total, page 1 of 2

RECRUITING

AETOS Shoulder System

NCT06319911

RECRUITING

Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry

NCT05915078

RECRUITING NA

Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears

NCT05444465

ACTIVE NOT RECRUITING

A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System

NCT06564636

ACTIVE NOT RECRUITING NA

To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.

NCT04849884

ACTIVE NOT RECRUITING

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036

ACTIVE NOT RECRUITING

Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA

NCT04325022

ACTIVE NOT RECRUITING

Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty

NCT03720782

ACTIVE NOT RECRUITING

Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts

NCT03687593

ACTIVE NOT RECRUITING

JOURNEY II XR Safety and Effectiveness PMCF

NCT03136887

ACTIVE NOT RECRUITING

JOURNEY™ II CR Total Knee System

NCT02440672

ACTIVE NOT RECRUITING

LEGION Hinge Safety and Efficacy Study

NCT02445443

NOT YET RECRUITING

A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

NCT07199738

COMPLETED

Safety and Performance Study of the FAST-FIX FLEX System for Meniscal Repairs and Meniscal Transplantations

NCT04903106

COMPLETED NA

Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

NCT04786119

COMPLETED

Safety of Treatment of Shoulder Repair

NCT04552119

TERMINATED NA

REGENETEN™ Bioinductive Implant System in Full-thickness Tears

NCT04450342

TERMINATED

Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears

NCT04361487

COMPLETED

Safety and Performance of ENTACT Septal Staple System for Septoplasty

NCT04392583

TERMINATED

Safety Study of Treatment of Leg Fractures

NCT03881241

COMPLETED

Safety and Performance of MICRORAPTOR™ Suture Anchors in Shoulder and Hip

NCT03985839

COMPLETED

PMCF Study on PEEK Suture Anchors for Hip Indications

NCT03814044

COMPLETED

Safety and Performance of JOURNEY™ II Cruciate Retaining (CR) Total Knee System (TKS)

NCT03885531

COMPLETED

Safety and Performance of PEEK Anchors in Extremities

NCT03782298

COMPLETED

PMCF Study on PEEK Suture Anchors for Shoulder Indications

NCT03826667

TERMINATED NA

Treatment of Partial-Thickness Rotator Cuff Tears

NCT03734536

COMPLETED

Safety and Performance of Journey II XR Total Knee System

NCT03798847

COMPLETED

Safety and Performance of the TFCC FastFix in the Wrist

NCT03756714

TERMINATED NA

Safety Study of Femoral Neck Fracture System

NCT03721835

COMPLETED

S&P of Q-Fix™ All-Suture Anchor System

NCT03594071

COMPLETED

Safety and Performance of the Journey™ II UNI Unicompartmental Knee System

NCT03768128

COMPLETED

Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome Measures

NCT03903731

COMPLETED

R3 Delta Ceramic Acetabular System PAS U.S.

NCT03056534

COMPLETED

Navio With Total Knee Arthroplasty

NCT03317834

COMPLETED

BIOSURE™ RG Knee Safety & Performance Study

NCT03519555

COMPLETED NA

Agili-C™ Implant Performance Evaluation

NCT03299959

TERMINATED

Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement

NCT03250767

COMPLETED

A Retrospective Study of the Navio Robotic-assisted Surgical System

NCT03072459

COMPLETED NA

Evaluation Of An Advanced Borderless Dressing

NCT03146845

TERMINATED

Clinical Evaluation of the TITAN™ Total Shoulder System

NCT03245320

COMPLETED

Predictors of Early Success From Circumferential Compression STITCH Meniscal Repairs

NCT03097744

COMPLETED

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003

TERMINATED

Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting

NCT02820766

TERMINATED Phase 4

Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers

NCT02718625

COMPLETED NA

Achilles Tendon Repair With Bioinductive Implant

NCT02811003

COMPLETED

Rotation Medical Bioinductive Implant Database Registry

NCT02784600

TERMINATED

REDAPT Retrospective-Prospective Modular Stem Study

NCT02661620

COMPLETED Phase 4

Use of Santyl in Diabetic Foot Ulcers

NCT02581488

COMPLETED NA

Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)

NCT02470806

COMPLETED NA

Study of Suture Repair of Torn Meniscus in the Knee

NCT02237001

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What the Pipeline for Smith & Nephew Shows

According to the ClinicalTrials.gov registry, Smith & Nephew is linked to 72 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 39 are already marked complete, representing roughly 54% of the total.

The phase mix for Smith & Nephew reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 0 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Smith & Nephew is Total Knee Arthroplasty with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.