Smith & Nephew

Open enrollment with a later-stage pipeline tilt

According to ClinicalTrials.gov-derived indexes, Smith & Nephew sits in the top decile of US sponsors by registered trial count (#300 of 15,742 sponsors by registered trial count).

72 total trials 3 currently recruiting 39 completed later-stage tilt top decile by trial count

Smith & Nephew: 72 sponsored US clinical trials, 3 recruiting.

Smith & Nephew sponsors 72 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 39 completed. 4 of these trials are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Total Knee Arthroplasty, with 3 trials.

Top-decile sponsor footprint

Smith & Nephew ranks in the top decile of sponsors by registered trial count (#300 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 4/100

39 of 59 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (66.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

72 total, page 2 of 2

TERMINATED

TITAN™ Reverse Shoulder System

NCT02204228

COMPLETED NA

Post-Market Evaluation of the Rotation Medical Rotator Cuff System

NCT02200939

TERMINATED NA

A RCT to Compare the Effects of Two Wound Products on Biofilm Disruption in DFUs

NCT02181621

TERMINATED NA

Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions

NCT01803880

TERMINATED NA

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772

COMPLETED NA

PICO Breast Reduction Clinical Study Looking at Incision Healing Complications

NCT01640366

COMPLETED

Safety and Efficacy of the Journey II BCS Total Knee System

NCT01705067

TERMINATED NA

TRIGEN SURESHOT™ Distal Targeting System Study

NCT01327508

COMPLETED

VISIONAIRE™ Value Study

NCT01107769

COMPLETED

R3® Acetabular System in Patients With Degenerative Hip Disease

NCT01407029

TERMINATED NA

LEGION™ Primary Safety and Efficacy

NCT04040985

TERMINATED NA

Ascension PyroCarbon Radial Head Study

NCT02405234

COMPLETED NA

Evaluation of the Use of EZCare/V1STA in the Management of Acute and Chronic Wounds

NCT00994162

TERMINATED Phase 4

Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy

NCT00613535

TERMINATED

INTUIT Hip Fracture Outcome Study

NCT00595634

COMPLETED NA

Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds

NCT01050673

COMPLETED

Ankle Joint Replacement Outcomes Study

NCT00503438

COMPLETED NA

A Safety and Efficacy Study of the Birmingham Hip Resurfacing System

NCT00611585

COMPLETED

A Study of Patients Treated With the Journey Deuce Bicompartmental Knee System

NCT01704326

COMPLETED Phase 4

Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers

NCT00521027

COMPLETED NA

Safety and Effectiveness Study of the Reflection Ceramic Acetabular System

NCT00663351

TERMINATED NA

Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis

NCT02408471

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Where Smith & Nephew enrollment is open (later-stage tilt)

3 recruiting of 72 indexed (4% open); 39 completed (54%).

Phase mix: 4 late (III/IV) vs 0 early (I/II) (later-stage heavy).

Top condition: Total Knee Arthroplasty (3 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Smith & Nephew: open-pipeline peers nationwide

Peers matched on 72 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

Smith & Nephew sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400 0%5%10%15%20%25% Total trials Recruiting share Smith & NephewH. Lundbeck A/SUniversity of California, BerkeleyDenver Health and Hospital AuthorityHugo W. Moser Research Institute at Kennedy KriegerAkebia TherapeuticsDentsply Sirona Implants and ConsumablesNational Institute on Drug Abuse (NIDA)Medtronic - MITG
Smith & Nephew sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Smith & Nephew sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 72 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this Smith & Nephew page

72 registered trials is a research-attention snapshot, not an endorsement of Smith & Nephew or any single study.

  • 3 of Smith & Nephew's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Total Knee Arthroplasty is the condition Smith & Nephew studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Total Knee Arthroplasty trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Smith & Nephew pipeline card: 72 registered trials from official public datasets.Report a data error.