Shire
Shire sponsors 245 registered US clinical trials on ClinicalTrials.gov, 1 of them currently recruiting, and 212 completed. 118 of these trials are in Phase 3-4 (later-stage) and 108 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 6 trials.
Trial Pipeline
245 total, page 5 of 5
A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)
NCT00500149
Strategies in Maintenance for Patients Receiving Long-term Therapy (S.I.M.P.L.E.) With MMX (Multi-Matrix System) Mesalamine for Ulcerative Colitis (UC)
NCT00446849
Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)
NCT00457015
Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE)
NCT00456508
Long-term Effect of Lanthanum Carbonate on Bone
NCT00557323
Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers
NCT00399308
Head to Head Study Against Sevelamer Hydrochloride
NCT00441545
Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients
NCT00411645
SPD503 (Guanfacine Hydrochloride) in ADHD Plus Oppositional Symptoms
NCT00367835
Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects
NCT00432510
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
NCT00438815
A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide
NCT00820885
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
NCT00462709
Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)
NCT00567723
Efficacy and Safety of Lanthanum Carbonate in Reducing Serum Phosphorus Levels in Subjects With Stage 3 and 4 Chronic Kidney Disease
NCT00234702
Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)
NCT00262080
Hunter Outcome Survey (HOS)
NCT03292887
Safety and Efficacy of SPD465 in Adults With ADHD
NCT00202605
Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
NCT00151892
C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
NCT00289211
C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
NCT01005888
Open Label Extension
NCT00172120
Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458)
NCT00172185
Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema
NCT00097695
Maribavir for Prevention of CMV After Stem Cell Transplants
NCT00223925
Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase
NCT00630747
Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension
NCT00555880
Replagal Enzyme Replacement Therapy for Children With Fabry Disease
NCT00084084
Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome
NCT00081458
Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease Who Completed Protocol CL0600-008
NCT00308438
ADDERALL XR (Mixed Salts of a Single-entity Amphetamine) and STRATTERA ( Atomoxetine Hydrochloride) Compared to Placebo on Simulated Driving Safety and Performance and Cognitive Functioning in Adults With ADHD
NCT00557960
Calcium Supplementation in Postmenopausal Women
NCT00172172
Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches
NCT00172094
Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease
NCT00072839
Safety and Efficacy of SPD476 (Mesalazine) Given Twice Daily (2.4 g/Day) vs SPD476 Given as a Single Dose (4.8 g/Day) in Subjects With Acute Mild to Moderate Ulcerative Colitis
NCT00503243
Iduronate-2-sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPS II)
NCT00069641
Analog Classroom Study Comparison of ADDERALL XR With STRATTERA in Children Aged 6-12 With ADHD
NCT00506727
Safety and Efficacy of ADDERALL XR in the Treatment of Adolescents Aged 13-17 With Attention Deficit Hyperactivity Disorder (ADHD)
NCT00507065
A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension
NCT00046163
Open Label Extension Study of PREOS
NCT00172133
Fabry Outcome Survey (FOS)
NCT03289065
Troxacitabine in Treating Patients With Chronic Myelogenous Leukemia
NCT00012259
TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis
NCT00172081
A Study for Patients With Neurogenic Orthostatic Hypotension
NCT00046475
A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis
NCT00172107
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 52 |
| Phase 2 | 56 |
| Phase 3 | 98 |
| Phase 4 | 20 |
What the Pipeline for Shire Shows
According to the ClinicalTrials.gov registry, Shire is linked to 245 US clinical trials across every stage of research activity. Of those, 1 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 212 are already marked complete, representing roughly 87% of the total.
The phase mix for Shire reports 118 late-stage studies (Phase 3 and Phase 4 combined) and 108 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Shire is Healthy with 6 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.