Shire

245 total trials 1 currently recruiting 212 completed

Shire sponsors 245 registered US clinical trials on ClinicalTrials.gov, 1 of them currently recruiting, and 212 completed. 118 of these trials are in Phase 3-4 (later-stage) and 108 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 6 trials.

Trial Pipeline

245 total, page 5 of 5

COMPLETED Phase 3

A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)

NCT00500149

COMPLETED Phase 4

Strategies in Maintenance for Patients Receiving Long-term Therapy (S.I.M.P.L.E.) With MMX (Multi-Matrix System) Mesalamine for Ulcerative Colitis (UC)

NCT00446849

COMPLETED Phase 3

Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)

NCT00457015

COMPLETED Phase 3

Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE)

NCT00456508

COMPLETED

Long-term Effect of Lanthanum Carbonate on Bone

NCT00557323

COMPLETED Phase 1

Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers

NCT00399308

COMPLETED Phase 3

Head to Head Study Against Sevelamer Hydrochloride

NCT00441545

COMPLETED Phase 3

Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients

NCT00411645

COMPLETED Phase 3

SPD503 (Guanfacine Hydrochloride) in ADHD Plus Oppositional Symptoms

NCT00367835

COMPLETED Phase 1

Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects

NCT00432510

COMPLETED Phase 3

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

NCT00438815

COMPLETED Phase 1

A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide

NCT00820885

COMPLETED Phase 3

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks

NCT00462709

COMPLETED

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

NCT00567723

COMPLETED Phase 2

Efficacy and Safety of Lanthanum Carbonate in Reducing Serum Phosphorus Levels in Subjects With Stage 3 and 4 Chronic Kidney Disease

NCT00234702

COMPLETED Phase 3

Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)

NCT00262080

COMPLETED

Hunter Outcome Survey (HOS)

NCT03292887

COMPLETED Phase 2

Safety and Efficacy of SPD465 in Adults With ADHD

NCT00202605

COMPLETED Phase 3

Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis

NCT00151892

COMPLETED Phase 3

C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

NCT00289211

COMPLETED Phase 3

C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks

NCT01005888

COMPLETED Phase 3

Open Label Extension

NCT00172120

COMPLETED Phase 3

Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458)

NCT00172185

COMPLETED Phase 3

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema

NCT00097695

COMPLETED Phase 2

Maribavir for Prevention of CMV After Stem Cell Transplants

NCT00223925

COMPLETED Phase 2

Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase

NCT00630747

COMPLETED Phase 4

Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension

NCT00555880

COMPLETED Phase 2

Replagal Enzyme Replacement Therapy for Children With Fabry Disease

NCT00084084

COMPLETED Phase 3

Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome

NCT00081458

COMPLETED Phase 2

Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease Who Completed Protocol CL0600-008

NCT00308438

COMPLETED Phase 3

ADDERALL XR (Mixed Salts of a Single-entity Amphetamine) and STRATTERA ( Atomoxetine Hydrochloride) Compared to Placebo on Simulated Driving Safety and Performance and Cognitive Functioning in Adults With ADHD

NCT00557960

COMPLETED Phase 3

Calcium Supplementation in Postmenopausal Women

NCT00172172

COMPLETED Phase 2

Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches

NCT00172094

COMPLETED Phase 2

Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease

NCT00072839

COMPLETED Phase 3

Safety and Efficacy of SPD476 (Mesalazine) Given Twice Daily (2.4 g/Day) vs SPD476 Given as a Single Dose (4.8 g/Day) in Subjects With Acute Mild to Moderate Ulcerative Colitis

NCT00503243

COMPLETED Phase 2

Iduronate-2-sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPS II)

NCT00069641

COMPLETED Phase 4

Analog Classroom Study Comparison of ADDERALL XR With STRATTERA in Children Aged 6-12 With ADHD

NCT00506727

COMPLETED Phase 3

Safety and Efficacy of ADDERALL XR in the Treatment of Adolescents Aged 13-17 With Attention Deficit Hyperactivity Disorder (ADHD)

NCT00507065

TERMINATED Phase 4

A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension

NCT00046163

COMPLETED Phase 3

Open Label Extension Study of PREOS

NCT00172133

COMPLETED

Fabry Outcome Survey (FOS)

NCT03289065

COMPLETED Phase 2

Troxacitabine in Treating Patients With Chronic Myelogenous Leukemia

NCT00012259

COMPLETED Phase 3

TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis

NCT00172081

COMPLETED Phase 4

A Study for Patients With Neurogenic Orthostatic Hypotension

NCT00046475

COMPLETED Phase 2

A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis

NCT00172107

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What the Pipeline for Shire Shows

According to the ClinicalTrials.gov registry, Shire is linked to 245 US clinical trials across every stage of research activity. Of those, 1 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 212 are already marked complete, representing roughly 87% of the total.

The phase mix for Shire reports 118 late-stage studies (Phase 3 and Phase 4 combined) and 108 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Shire is Healthy with 6 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.