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ClinicalTrials.gov 4 recruiting now official registry

Hypoparathyroidism clinical trials

4 of 11 indexed Hypoparathyroidism trials are currently recruiting.

11 US clinical trials · 4 currently recruiting

Hypoparathyroidism is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Shire, running 3 of these trials.

The research picture

Hypoparathyroidism has 11 registered US clinical trials, 4 of them open to new participants right now, about 36% of the total.

4
recruiting participants now
36%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
3
top sponsor: Shire
Phase 11Phase 22Phase 31Phase 43

Active & Recent Trials

11 total, page 1 of 1

RECRUITING 106 participants

Hypoparathyroidism Natural History Study

Columbia University

NCT05793853

RECRUITING 100 participants

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Bettina Mittendorfer

NCT07083557

RECRUITING 50 participants

A Global Pregnancy Registry to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to YORVIPATH® (Palopegteriparatide) During Pregnancy and Breastfeeding

Ascendis Pharma A/S

NCT07345494

RECRUITING Phase 1 3 participants

Parathyroid Allotransplant for Treatment of Hypoparathyroidism

Peter Stock

NCT06961071

ACTIVE NOT RECRUITING 1,339 participants

A Registry for Participants With Chronic Hypoparathyroidism

Takeda

NCT01922440

ACTIVE NOT RECRUITING Phase 2 60 participants

Extension Study to Evaluate the Long-Term Safety and Tolerability of MBX 2109 in Patients With Hypoparathyroidism

MBX Biosciences

NCT06531941

COMPLETED Phase 3 124 participants

Use of NPSP558 in the Treatment of Hypoparathyroidism

Shire

NCT00732615

COMPLETED Phase 4 93 participants

A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE)

Shire

NCT03324880

COMPLETED Phase 2 64 participants

Safety, Pharmacokinetics and Efficacy of MBX 2109 in Patients With Hypoparathyroidism

MBX Biosciences

NCT06465108

COMPLETED Phase 4 39 participants

A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism

Shire

NCT02910466

COMPLETED Phase 4 19 participants

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

University of Wisconsin, Madison

NCT00581828

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 1
Phase 4 3

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypoparathyroidism Trial Landscape

11 indexed Hypoparathyroidism studies · 4 recruiting (36%).

Phase mix: 4 late (III/IV) vs 3 early (I/II).

Top sponsor: Shire (3 trials), 7 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypoparathyroidism?

PlainTrial tracks 11 US clinical trials for Hypoparathyroidism, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypoparathyroidism?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.