Mayo Clinic

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Mayo Clinic sits in the top decile of US sponsors by registered trial count (#2 of 15,742 sponsors by registered trial count).

2,844 total trials 544 currently recruiting 1816 completed early-phase tilt top decile by trial count

Mayo Clinic: 2,844 sponsored US clinical trials, 544 recruiting.

Mayo Clinic sponsors 2,844 registered US clinical trials on ClinicalTrials.gov, 544 of them currently recruiting, and 1,816 completed. 252 of these trials are in Phase 3-4 (later-stage) and 821 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 36 trials.

Top-decile sponsor footprint

Mayo Clinic ranks in the top decile of sponsors by registered trial count (#2 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 56/100

1,816 of 2,102 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

2,844 total, page 48 of 57

COMPLETED NA

A Phase I Study of iPS Cell Generation From Patients With COPD

NCT01860898

COMPLETED Phase 1

Everolimus, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Unresectable Solid Tumors Refractory to Standard Therapy

NCT00949949

COMPLETED NA

EUS Guided Celiac Neurolysis

NCT01615653

COMPLETED Phase 2

Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS)

NCT01253408

COMPLETED Phase 2

Varenicline and Bupropion for Smoking Cessation

NCT00935818

COMPLETED

Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)

NCT01222182

COMPLETED Phase 1

Effects of Gastric Antral Botulinum Toxin Injections in Obese Subjects

NCT00976443

COMPLETED

Biomarkers for Human Heart Failure

NCT03905252

COMPLETED

Identifying Factors Underlying the Discontinuation of Triptans

NCT00890357

COMPLETED

Registry for Study of Coils in Intracranial Aneurysms

NCT01000675

COMPLETED Phase 4

The Effect of Welchol on Glucose Metabolism in Type 2 Diabetics

NCT00951899

COMPLETED Phase 1

Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC)

NCT00955149

COMPLETED

Serum Procalcitonin

NCT00954551

COMPLETED Phase 1

Everolimus and Alemtuzumab in Treating Patients With Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT00935792

COMPLETED Phase 1

The Effects of Decreasing the Lasix Dose on the Cardiorenal System

NCT00982423

TERMINATED Phase 1

Stereotactic Radiation Therapy in Treating Patients With Liver Metastases

NCT00938457

TERMINATED Phase 2

Leuprolide Acetate or Goserelin Acetate Compared With Observation in Treating Patients With High-Risk Prostate Cancer Who Have Undergone Radical Prostatectomy

NCT00937768

TERMINATED Phase 1

Evaluate Use of Mangosteen Juice Added to Usual Care in Reducing Risk of Recurrent Atrial Fibrillation

NCT00951301

COMPLETED Phase 1

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

NCT00918333

COMPLETED Phase 4

Greater Occipital Nerve Block for Migraine Prophylaxis

NCT00915473

COMPLETED Phase 1

Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis (PBC)

NCT00943176

COMPLETED Phase 4

Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy

NCT00934999

COMPLETED Phase 1

Role of Endogenous Estrogen in Growth-Hormone Regulation in Postmenopausal Women

NCT01186796

COMPLETED Phase 1

A Pilot Study of Renal Hypothermia During Partial Nephrectomy

NCT00888641

COMPLETED

Indigo Carmine Staining and Narrow Band Imaging (NBI) of Colonic Mucosa for Detection of Dysplasia in Ulcerative Colitis

NCT00961948

COMPLETED

Effect of Surgery and Radiation Therapy on Tc-99M Sestamibi Uptake Patterns in Molecular Breast Imaging

NCT01027767

COMPLETED NA

Wiser Choices in Osteoporosis Choice II: A Decision Aid for Patients and Clinicians

NCT00949611

TERMINATED

Breath Test for Women Receiving Tamoxifen in the Prevention or Treatment of Breast Cancer

NCT00873366

COMPLETED Early Phase 1

Pentoxifylline Treatment of Acute Pancreatitis

NCT01292005

COMPLETED

Fiber Formula Study Among Radiation Oncology Patients

NCT00888147

COMPLETED Phase 1

An Open Label Study of the Effects of Eculizumab in Neuromyelitis Optica

NCT00904826

COMPLETED Phase 2

Effect of Vitamin D3 Supplementation on Insulin Resistance and Cardiovascular Risk Factors in Obese Adolescents

NCT00858247

COMPLETED Phase 2

Cheno Effect on Transit in Health and IBS-C

NCT00912301

COMPLETED Early Phase 1

Stellate Ganglion Nerve Block in Treating Women With Hot Flashes

NCT00879164

COMPLETED

HISTOACRYL: A Study of Its Efficacy in Final Scar Formation

NCT00890578

COMPLETED NA

Low Dose Molecular Breast Imaging as a Screening Tool for Women With Dense Breasts

NCT01925170

TERMINATED NA

Confocal Endomicroscopy for Biliary Strictures -Phase I

NCT00892632

COMPLETED Phase 1

Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery

NCT01839812

COMPLETED

Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery

NCT00984672

COMPLETED NA

Wiser Choices in Acute Myocardial Infarction

NCT00888537

COMPLETED

Lung Injury Prediction Study

NCT00889772

COMPLETED Phase 2

Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT00816595

COMPLETED NA

Varenicline for the Treatment of Smokeless Tobacco

NCT00813917

COMPLETED Phase 1

Hemin in Healthy Subjects

NCT00882804

COMPLETED

Intestinal Wall Remodeling (Infliximab Therapy) in Crohn's Disease Patients Undergoing Serial Computed Tomography (CT) Enterography

NCT00819663

COMPLETED

The Use of Molecular Breast Imaging in the Evaluation of Tumor Response to Neoadjuvant Therapy in Women With Breast Cancer

NCT01023802

COMPLETED NA

Lp-PLA2 and Coronary Atherosclerosis in Humans

NCT01557088

COMPLETED Phase 4

Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy

NCT00498368

COMPLETED Phase 1

A Pilot Study to Examine the Role of Nitazoxanide to Prevent Recurrence of Hepatitis C After Transplantation

NCT01074203

TERMINATED Phase 1

B-type Natriuretic Peptide (BNP) in Human Hypertension

NCT00953472

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Phase Distribution

PhaseTrial count
Phase 1 435
Phase 2 386
Phase 3 86
Phase 4 166

What is open in the Mayo Clinic pipeline

544 recruiting of 2,844 indexed (19% open); 1,816 completed (64%).

Phase mix: 252 late (III/IV) vs 821 early (I/II) (early-phase heavy).

Top condition: Healthy (36 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Mayo Clinic: open-pipeline peers nationwide

Peers matched on 2,844 registered trials and 19% open enrollment, not the therapeutic-area sidebar.

Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 01,0002,0003,0004,000 5%10%15%20%25% Total trials Recruiting share Mayo ClinicM.D. Anderson Cancer CenterNational Cancer Institute (NCI)Massachusetts General HospitalNational Institute of Allergy and Infectious Diseases (NIAID)University of South CarolinaVanderbilt University Medical CenterMemorialCare Health SystemUniversity of North Texas Health Science Center
Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 2,844 trials (± recruiting share)

Sponsors near 19% open enrollment (± trial volume)

What to do with this Mayo Clinic page

2,844 registered trials is a research-attention snapshot, not an endorsement of Mayo Clinic or any single study.

  • 544 of Mayo Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition Mayo Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Mayo Clinic pipeline card: 2,844 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.