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NCT01557088 · ClinicalTrials.gov registry record · NA
Lp-PLA2 and Coronary Atherosclerosis in Humans
A NA study, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 166
- Enrollment target
NCT01557088: Completed NA study, sponsored by Mayo Clinic.
NCT01557088 is a NA study that has completed, run by Mayo Clinic. The registered enrollment target is 166 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01557088, a NA study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 166 participants
- Enrollment target
Study Summary
The majority of the acute coronary events are caused by coronary artery segments with minimal luminal disease, but with potentially significant vascular wall inflammation and oxidative stress leading to plaque vulnerability. It has become apparent that an initial injury at the endothelial surface, is the primary site of the mechanisms involved and a role for vascular inflammation and the interaction with oxidative stress continues to emerge. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker for vascular wall inflammation that circulates in the blood bound to both low density (LDL) and high density (HDL) lipoprotein and promotes vascular inflammation. Circulating levels of Lp-PLA2 mass and activity are an independent risk factor for cardiovascular events. Recent studies, demonstrating that Lp-PLA2 is also associated with coronary endothelial dysfunction. However, the relationship between Lp-PLA2 and early atherosclerotic changes in the coronary arteries, and the contribution of lipoprotein binding to the deleterious potential of Lp- PLA2 have not been elucidated. Our working hypothesis is that the endogenous local activation of the Lp-PLA2 pathway plays an integral role in early coronary atherosclerosis and contributes to the mechanism of coronary endothelial dysfunction and the structural and mechanical properties reflecting plaque vulnerability. Thus, the current application will characterize prospectively the correlation between the functional, mechanical, and structural vascular wall properties, and the systemic as well as the coronary activity of the Lp-PLA2 pathway.
Interventions
- OTHER Blood sampling from the Coronary Sinus and Aorta
- PROCEDURE Intravascular Ultrasound of the coronary artery.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 166 participants |
| Start Date | 2009-02 |
| Est. Completion | 2015-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01557088
The ClinicalTrials.gov registry entry for NCT01557088 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 166 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Blood sampling from the Coronary Sinus and Aorta is the first listed.
NCT01557088 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01557088 about?
NCT01557088 is a clinical study titled "Lp-PLA2 and Coronary Atherosclerosis in Humans". The majority of the acute coronary events are caused by coronary artery segments with minimal luminal disease, but with potentially significant vascular wall inflammation and oxidative stress leading to plaque vulnerability. It has become apparent that an initial injury at the endothelial surface, i...
What is the current status of trial NCT01557088?
This trial is currently completed. It is a NA study. The enrollment target is 166 participants. The study started on 2009-02. Estimated completion is 2015-06.
What interventions are being tested in trial NCT01557088?
The interventions under investigation include: Blood sampling from the Coronary Sinus and Aorta (OTHER), Intravascular Ultrasound of the coronary artery. (PROCEDURE).
Who is sponsoring clinical trial NCT01557088?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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