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NCT00953472 · ClinicalTrials.gov registry record · Phase 1
B-type Natriuretic Peptide (BNP) in Human Hypertension
A Phase 1 study, sponsored by Mayo Clinic.
- Terminated
- Registry status
- Phase 1
- Development phase
- 8
- Enrollment target
NCT00953472: Clinical Trial Phase 1 study, sponsored by Mayo Clinic.
NCT00953472 is a Phase 1 study that was terminated before completion, run by Mayo Clinic. The registered enrollment target is 8 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00953472, a Phase 1 study, was terminated before completion, sponsored by Mayo Clinic.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 8 participants
- Enrollment target
Study Summary
The investigators working hypothesis is that human hypertension is in part due to a derangement in the endocrine function of the heart - a primary or secondary mechanism - resulting in a relative deficiency of the natriuretic peptides (NP). The remodeled hypertensive heart could result in altered processing and degradation of B-type NP resulting in altered molecular forms with decreased biological activity. The investigators further hypothesized the chronic administration of BNP in subjects with hypertension, is feasible, safe and will induce a sustained reduction in blood pressure.
Interventions
- DRUG brain natriuretic peptide
- OTHER no-added salt diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2009-02 |
| Est. Completion | 2011-04 |
| Phase | Phase 1 |
Why NCT00953472 stopped before completion
NCT00953472 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 2 interventions - of which brain natriuretic peptide is the first listed.
NCT00953472 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00953472 about?
NCT00953472 is a clinical study titled "B-type Natriuretic Peptide (BNP) in Human Hypertension". The investigators working hypothesis is that human hypertension is in part due to a derangement in the endocrine function of the heart - a primary or secondary mechanism - resulting in a relative deficiency of the natriuretic peptides (NP). The remodeled hypertensive heart could result in altered pr...
What is the current status of trial NCT00953472?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 8 participants. The study started on 2009-02. Estimated completion is 2011-04.
What interventions are being tested in trial NCT00953472?
The interventions under investigation include: brain natriuretic peptide (DRUG), no-added salt diet (OTHER).
Who is sponsoring clinical trial NCT00953472?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00953472's enrollment target sits among peer trials
8 1959th of 2000 higher than 29 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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