Massachusetts General Hospital

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Massachusetts General Hospital sits in the top decile of US sponsors by registered trial count (#4 of 15,751 sponsors by registered trial count).

2,032 total trials 336 currently recruiting 1284 completed early-phase tilt top decile by trial count

Massachusetts General Hospital: 2,032 sponsored US clinical trials, 336 recruiting.

Massachusetts General Hospital sponsors 2,032 registered US clinical trials on ClinicalTrials.gov, 336 of them currently recruiting, and 1,284 completed. 240 of these trials are in Phase 3-4 (later-stage) and 515 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Depression, with 29 trials.

Top-decile sponsor footprint

Massachusetts General Hospital ranks in the top decile of sponsors by registered trial count (#4 of 15,751 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

2,032 total, page 16 of 41

COMPLETED

To Observe Whether Isoflurane Can Treat COVID-19 Patients

NCT04492943
COMPLETED Phase 3

Efficacy of Tocilizumab on Patients With COVID-19

NCT04356937
TERMINATED Phase 2

Nitric Oxide Inhalation Therapy for COVID-19 Infections in the ED

NCT04338828
TERMINATED

Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection

NCT04356443
TERMINATED Phase 2

NO Prevention of COVID-19 for Healthcare Providers

NCT04312243
COMPLETED

Developing a Down Syndrome Health Instrument

NCT04631237
COMPLETED Phase 3

Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease

NCT04332991
COMPLETED

The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2)

NCT04051333
COMPLETED Phase 2

Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19

NCT04306393
TERMINATED Phase 2

Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

NCT04305457
COMPLETED

Online Trial Examining Validity and Reliability of the Shared Decision Making Process Survey

NCT04317690
COMPLETED NA

Online Trial Examining Validity of the Shared Decision Making Process Survey With Video Vignettes

NCT04317274
TERMINATED NA

A Trial of Traffic Light Labeling With Behavioral Nudges and a Healthy Recipe Database to Increase Selection of Healthier Foods in Client-choice Food Pantries

NCT04243252
TERMINATED NA

TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory

NCT04294888
COMPLETED

COVID-19 Testing Sample Acquisition Throughput and Efficiency

NCT04532411
TERMINATED NA

Pilot Study of the Haymakers for Hope Fitness Program

NCT04220216
COMPLETED NA

PEERS Using Peer Mentors to Deliver Depression Care

NCT04319094
COMPLETED Phase 4

Immune Monitoring to Facilitate Belatacept Monotherapy

NCT04177095
COMPLETED NA

Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus

NCT04187521
COMPLETED

Telemedicine Abdominal Exams & Imaging

NCT04254588
COMPLETED

Inflammation and Cardiovascular Health in Women

NCT04224181
COMPLETED Phase 4

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

NCT04020718
COMPLETED NA

School-Based Living In Families With Emotions Training

NCT06793878
COMPLETED NA

Evaluation of a Resiliency Intervention for Siblings of Children With Autism Spectrum Disorder (ASD)

NCT04369417
COMPLETED Phase 2

Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Treatment in Spinal Surgery

NCT05764707
COMPLETED NA

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

NCT03904186
COMPLETED

Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

NCT04195061
TERMINATED NA

Text-Enabled Ascertainment and Community Linkage for Health

NCT04058301
COMPLETED Early Phase 1

rTMS as a Treatment for PPA

NCT03406429
COMPLETED NA

Connect for Health Pediatric Weight Management Program

NCT04042493
COMPLETED NA

Electronic Pill Bottle Monitoring to Promote Medication Adherence for People With Multiple Sclerosis

NCT04130256
TERMINATED Phase 4

Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain

NCT03891264
COMPLETED Phase 4

A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.

NCT03811847
COMPLETED

Effects of Gender-Affirming Hormone Therapy Among Transgender Women

NCT04128488
COMPLETED NA

The Effects of Exercise on Sleep and Brain Health

NCT04210882
COMPLETED NA

Small-group, Virtual Program for Improving Symptoms and Distress Related to Hormonal Therapy for Breast Cancer Survivors

NCT03837496
COMPLETED NA

Auricular Vagus Nerve Stimulation for Chronic Pain

NCT03959111
COMPLETED

Executive Function and Symptom Reduction in Youth Receiving Home-based Treatment With Collaborative Problem Solving

NCT04121650
COMPLETED NA

Psychological Intervention For Brain Tumor Caregivers

NCT04109209
TERMINATED Phase 2

Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)

NCT04057365
COMPLETED NA

A Tailored Program to Promote Well-being and Physical Activity in Mid-life Adults With Low Physical Activity

NCT04745182
COMPLETED

HIV Exposure in Utero and Metabolic Disease Risk in HIV-Negative Young Adults

NCT04132830
TERMINATED NA

Early Insertion of Axillary Impella® With VA ECMO

NCT04084015
COMPLETED NA

Impact of a Patient Decision Aid for Treatment of Aortic Stenosis

NCT04103931
COMPLETED NA

Waitlist-Control Trial of Smartphone Cognitive Behavioral Therapy (CBT) for Body Dysmorphic Disorder (BDD)

NCT03673046
COMPLETED NA

Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain

NCT04044183
COMPLETED Phase 1

Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease

NCT04031729
COMPLETED Phase 4

Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration

NCT04026256
COMPLETED Phase 4

Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval

NCT03073980
TERMINATED Phase 2

Umbralisib and Rituximab as Initial Therapy for Patients With Follicular Lymphoma and Marginal Zone Lymphoma

NCT03919175
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Phase Distribution

PhaseTrial count
Phase 1 226
Phase 2 289
Phase 3 58
Phase 4 182

Therapeutic Areas

Depression 29
Major Depressive Disorder 19
Breast Cancer 16
Lung Cancer 15
Multiple Myeloma 14
Obesity 13
Healthy 12
Cancer 12
Schizophrenia 11
Bipolar Disorder 11

What is open in the Massachusetts General Hospital pipeline

336 recruiting of 2,032 indexed (17% open); 1,284 completed (63%).

Phase mix: 240 late (III/IV) vs 515 early (I/II) (early-phase heavy).

Top condition: Depression (29 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Related

Compare saved trials side-by-side

Read our methodology - how this data is sourced, computed, and verified.
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.