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NCT04294888 · ClinicalTrials.gov registry record · NA
TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory
A NA study, sponsored by Massachusetts General Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT04294888: Clinical Trial NA study, sponsored by Massachusetts General Hospital.
NCT04294888 is a NA study that was terminated before completion, run by Massachusetts General Hospital. The registered enrollment target is 4 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04294888, a NA study, was terminated before completion, sponsored by Massachusetts General Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD). This study will use repetitive Transcranial Magnetic Stimulation (rTMS) to stimulate nodes of the Default Mode Network (DMN)- which is thought to support episodic memory and to be affected by Alzheimer's pathology. We will use functional connectivity MRI (fcMRI) to assess changes in functional network architecture following the stimulation. We will also assess putative cognitive improvements resulting from the stimulation by in-depth memory testing.
Primary Outcome
A test of memory for face-name associations
Interventions
- DEVICE repetitive transcranial magnetic stimulation (rTMS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2020-03-02 |
| Est. Completion | 2021-06-23 |
| Phase | NA |
Why NCT04294888 stopped before completion
NCT04294888 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which repetitive transcranial magnetic stimulation (rTMS) is the first listed.
NCT04294888 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04294888 about?
NCT04294888 is a clinical study titled "TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory". The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD). This study will use repetitive Transcranial Magnetic Stimulation (rTMS) to ...
What is the current status of trial NCT04294888?
This trial is currently terminated. It is a NA study. The enrollment target is 4 participants. The study started on 2020-03-02. Estimated completion is 2021-06-23.
What interventions are being tested in trial NCT04294888?
The interventions under investigation include: repetitive transcranial magnetic stimulation (rTMS) (DEVICE).
Who is sponsoring clinical trial NCT04294888?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04294888's enrollment target sits among peer trials
4 1996th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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