GlaxoSmithKline

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, GlaxoSmithKline sits in the top decile of US sponsors by registered trial count (#17 of 15,742 sponsors by registered trial count).

1,345 total trials 50 currently recruiting 1130 completed early-phase tilt top decile by trial count

GlaxoSmithKline: 1,345 sponsored US clinical trials, 50 recruiting.

GlaxoSmithKline sponsors 1,345 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 1,130 completed. 486 of these trials are in Phase 3-4 (later-stage) and 791 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Pulmonary Disease, Chronic Obstructive, with 30 trials.

Top-decile sponsor footprint

GlaxoSmithKline ranks in the top decile of sponsors by registered trial count (#17 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 66/100

1,130 of 1,249 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (90.5%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,345 total, page 27 of 27

COMPLETED Phase 1

A Dose-escalation Vaccine Trial in HER2-overexpressing Patients With High-risk Breast Cancer

NCT00058526

COMPLETED Phase 3

"REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk

NCT00056407

COMPLETED Phase 2

An 8 Week Depression Study In Adults Diagnosed With Major Depressive Disorder

NCT00057239

COMPLETED Phase 2

An 8 Week Study Of Depression In Adults Diagnosed With Major Depressive Disorder

NCT00057213

COMPLETED Phase 2

An 8 Week Study Of Adults Diagnosed With Major Depressive Disorder

NCT00057226

COMPLETED Phase 3

Bipolar Disorder Study for Men and Women

NCT00056277

COMPLETED Phase 3

A New Tablet Containing Two FDA-Approved Drugs In HIV-Infected Patients Who Have Not Received Prior Therapy

NCT00053638

COMPLETED Phase 4

GSK BHR Study (Sont)

NCT00920543

COMPLETED Phase 1

A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children

NCT00297206

COMPLETED Phase 3

HerpeVac Trial for Young Women

NCT00057330

COMPLETED Phase 1

Dose-Escalation Study Of SB-485232 Administered As Daily Subcutaneous Injections In Adults With Solid Tumors

NCT00085878

COMPLETED Phase 3

Effects Of Antidepressants On Sexual Functioning In Adults

NCT00051272

COMPLETED Phase 3

Effects of Antidepressants on Sexual Functioning

NCT00051259

COMPLETED Phase 4

GSK BHR Study (Sont - Second Study)

NCT01324362

COMPLETED Phase 2

Second-line Intravenous Treatment For Recurrent Platinum-Sensitive Ovarian, Fallopian, Or Peritoneal Cancer

NCT00061308

COMPLETED Phase 3

A Combined Tdap Vaccine Used As A Booster Compared To Licensed Td Vaccine

NCT00109330

COMPLETED Phase 2

The Study of GW493838, an Adenosine A1 Agonist, in Peripheral Neuropathic Pain

NCT00376454

COMPLETED Phase 2

Comparison of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP and IPV Separately Administered Vaccines in Terms of Immune Response and Safety

NCT00263692

COMPLETED Phase 2

Schizophrenia Study In Adults

NCT00049946

COMPLETED Phase 2

Oral Drug Study In Women With Refractory Metastatic Breast Cancer After First-line or Second-line Herceptin.

NCT00051103

COMPLETED Phase 3

Attention-Deficit Hyperactivity Disorder (ADHD) Study With Adults

NCT00048360

COMPLETED Phase 4

Rosiglitazone In Subjects With Type 2 Diabetes Mellitus Who Are Inadequately Controlled On Insulin

NCT00329225

COMPLETED Phase 4

Major Depressive Disorder Study In Adults

NCT00049972

COMPLETED Phase 3

Prevention of Seasonal Affective Disorder

NCT00046241

COMPLETED Phase 2

GW572016, An Oral Drug For Colorectal Cancer Patients Having Prior Therapy With 5-FU Plus CPT-11 And/Or Oxaliplatin

NCT00044343

COMPLETED Phase 3

Prevention of Seasonal Affective Disorder

NCT00046449

COMPLETED Phase 2

The Study Of An Oral Drug Called A Radiation Sensitizer In Patients With Newly Diagnosed Small Cell Lung Cancer (SCLC)

NCT00043862

COMPLETED Phase 2

A Study Comparing 4 Doses Of GW810781 Versus Placebo In HIV-Infected Patients

NCT00046332

COMPLETED Phase 3

Long-term Extension Study Evaluating Extended Release Ropinirole XL (Formerly Referred to as Ropinirole CR) in Patients Who Already Completed Either Study 167 or 164

NCT00650104

COMPLETED Phase 3

Study to Explore Safety And Tolerability of Fosamprenavir With or Without Ritonavir in Combination With TRIZIVIR or COMBIVIR

NCT00043888

TERMINATED Phase 1

Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer

NCT00158886

COMPLETED Phase 3

Advair Pediatric Once-Daily

NCT00920959

COMPLETED Phase 1

A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors

NCT00046111

COMPLETED Phase 4

Glycemic Control Of Carvedilol Versus Metoprolol In Patients With Type II Diabetes Mellitus And Hypertension

NCT00060918

COMPLETED Phase 4

Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension

NCT00060931

COMPLETED Phase 3

Extensive Small Cell Lung Cancer Treatment Using An Investigational Drug Plus Chemotherapy In Chemotherapy-Naive Adults

NCT00043927

COMPLETED Phase 4

Treatment Of Primary Generalized Tonic-Clonic Seizures With An Investigational New Drug

NCT00043901

COMPLETED Phase 2

Pediatric Epilepsy Study in Subjects 1-24 Months

NCT00044278

COMPLETED Phase 3

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

NCT00268216

COMPLETED Phase 2

Pediatric Epilepsy Trial in Subjects 1-24 Months

NCT00043875

COMPLETED Phase 2

Vinorelbine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

NCT00005865

COMPLETED Phase 3

Rosiglitazone on Microalbuminuria in Type 2 Diabetics

NCT00500955

COMPLETED Phase 3

Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide

NCT00279045

COMPLETED Phase 2

506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents

NCT00003635

COMPLETED Phase 3

Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects

NCT00698568

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Phase Distribution

PhaseTrial count
Phase 1 440
Phase 2 351
Phase 3 377
Phase 4 109

What is open in the GlaxoSmithKline pipeline

50 recruiting of 1,345 indexed (4% open); 1,130 completed (84%).

Phase mix: 486 late (III/IV) vs 791 early (I/II) (early-phase heavy).

Top condition: Pulmonary Disease, Chronic Obstructive (30 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

GlaxoSmithKline: open-pipeline peers nationwide

Peers matched on 1,345 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

GlaxoSmithKline sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 0%5%10%15% Total trials Recruiting share GlaxoSmithKlineEli Lilly and CompanyUniversity of MichiganNovartis PharmaceuticalsAstraZenecaStryker OrthopaedicsUS Oncology ResearchOtsuka Pharmaceutical Development & CommercializationTeva Branded Pharmaceutical Products R&D
GlaxoSmithKline sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

GlaxoSmithKline sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,345 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this GlaxoSmithKline page

1,345 registered trials is a research-attention snapshot, not an endorsement of GlaxoSmithKline or any single study.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. GlaxoSmithKline pipeline card: 1,345 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.