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ClinicalTrials.gov 1 recruiting now official registry

Herpes Zoster clinical trials

Every US clinical trial registered for Herpes Zoster — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

17 US clinical trials · 1 currently recruiting

The research picture

Herpes Zoster has 17 registered US clinical trials, 1 of them open to new participants right now — about 6% of the total.

1
recruiting participants now
6%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
8
top sponsor: GlaxoSmithKline

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 225 participants

Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05580458

ACTIVE NOT RECRUITING Phase 3 3,038 participants

A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults

GlaxoSmithKline

NCT05371080

ACTIVE NOT RECRUITING 2,844 participants

Safety of Herpes Zoster Subunit (HZ/su) Vaccine During Pregnancy in Adult Women With Immunocompromised Conditions

GlaxoSmithKline

NCT05811754

ACTIVE NOT RECRUITING Phase 2 1,516 participants

Safety and Immunogenicity of CRV-101 Vaccine for the Prevention of Herpes Zoster in Adults Aged 50 Years and Older

Curevo

NCT05304351

ACTIVE NOT RECRUITING Phase 1 659 participants

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age

ModernaTX

NCT05701800

ACTIVE NOT RECRUITING Phase 2 154 participants

The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept

Kevin Winthrop

NCT03604406

ACTIVE NOT RECRUITING Phase 1 150 participants

A Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants

Shenzhen Shenxin Biotechnology Co.

NCT06375512

COMPLETED Phase 3 14,819 participants

Study to Evaluate Efficacy, Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 70 Years and Older

GlaxoSmithKline

NCT01165229

COMPLETED Phase 3 8,687 participants

Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies.

GlaxoSmithKline

NCT02690207

COMPLETED Phase 3 913 participants

Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With Prevenar13 in Adults Aged 50 Years and Older

GlaxoSmithKline

NCT03439657

COMPLETED Phase 3 865 participants

Study to Evaluate Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A When Co-administered With Pneumovax 23™ in Adults Aged 50 Years and Older

GlaxoSmithKline

NCT02045836

COMPLETED Phase 2 410 participants

Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine With Various Formulations in Adults >= 50 Years

GlaxoSmithKline

NCT00802464

COMPLETED Phase 1 160 participants

Comparison of a Live Herpes Zoster Vaccine and a Recombinant Vaccine in 50-59 and 70-85 Year Olds

University of Colorado, Denver

NCT02114333

COMPLETED Phase 2 121 participants

Safety & Immunogenicity of GlaxoSmithKline Biologicals' Herpes Zoster Vaccine 1437173A

GlaxoSmithKline

NCT00920218

COMPLETED Phase 4 105 participants

Persistence of Protection by Shingrix

University of Colorado, Denver

NCT04169009

COMPLETED Phase 1 90 participants

Safety, Tolerability, and Immunogenicity of CRV-101 in Healthy Adult Subjects

Curevo

NCT03820414

COMPLETED 19 participants

Immune Response to Varicella-Zoster Vaccination and Infection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00921999

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 4
Phase 3 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Herpes Zoster Trial Landscape

ClinicalTrials.gov lists 17 US studies indexed under Herpes Zoster, and 1 of those are currently open to recruitment — roughly 6% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Herpes Zoster shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Herpes Zoster is led by GlaxoSmithKline with 8 indexed trials, alongside 6 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Herpes Zoster?

PlainTrial tracks 17 US clinical trials for Herpes Zoster, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Herpes Zoster?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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