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ClinicalTrials.gov 24,857 recruiting now free trial finder

Find a clinical trial that's recruiting now

Search 24,857 actively recruiting US clinical trials by condition, drug, or state, each entry links straight to its NIH ClinicalTrials.gov record so you can check eligibility and contact the study team.

24,857
trials recruiting now
14%
of all US trials open to enrollment
52
states with recruiting sites

A trial is listed as recruiting when its sponsor has marked it open to new participants on the public registry. Type a condition or drug name (for example, "breast cancer" or "pembrolizumab") to narrow the list, and add a state to find studies with a site near you. Results are ordered with the most relevant recruiting studies first; each card shows the study phase and enrollment target, and opens the full record, including eligibility criteria and contact details, on ClinicalTrials.gov.

Showing the 40 largest recruiting trials by target enrollment in South Dakota. Use the search field to focus on a condition or drug.

Recruiting 2,000,000 participants

Helix Research Network

Helix

NCT06057181

Recruiting 200,000 participants

Connect for Cancer Prevention Study (Connect)

National Cancer Institute (NCI)

NCT04609072

Recruiting NA 100,000 participants

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

University of California, San Francisco

NCT02620852

Recruiting 33,000 participants

General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery

Sanford Health

NCT04477928

Recruiting 25,000 participants

Avera Cancer Sequencing and Analytics Protocol (ASAP)

Avera McKennan Hospital & University Health Center

NCT05142033

Recruiting 20,000 participants

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Sanford Health

NCT01793168

Recruiting 10,000 participants

Umbrella Study for Analysis of Data Related to Patients With Cancer

Tempus AI

NCT06018753

Recruiting 4,500 participants

Investigations of Reproductive Cancers in Women

PinkDx

NCT06527157

Recruiting 3,500 participants

Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study

University of Michigan

NCT04831164

Recruiting 2,500 participants

MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.

Carolyn M Hettrich

NCT02075775

Recruiting 2,000 participants

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

University of Kansas Medical Center

NCT06425848

Recruiting 1,065 participants

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Merck Sharp & Dohme

NCT04165798

Recruiting NA 850 participants

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Boston Scientific Corporation

NCT07069738

Recruiting Phase 3 800 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Eli Lilly and Company

NCT07153471

Recruiting Phase 3 800 participants

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

Janssen Research & Development

NCT07225946

Recruiting Phase 1 768 participants

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Boehringer Ingelheim

NCT06324357

Recruiting Phase 3 710 participants

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

Daiichi Sankyo

NCT07022483

Recruiting NA 702 participants

Melodi Matrix™ in Breast Reconstruction

Melodi Health

NCT06027996

Recruiting Phase 3 674 participants

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

Celcuity

NCT06757634

Recruiting 550 participants

A Longitudinal Multi-Center Molecular Biomarker Discovery Registry for Patients With Hematologic Malignancies

Tempus AI

NCT07154823

Recruiting Phase 3 530 participants

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Bristol-Myers Squibb

NCT06646276

Recruiting Phase 3 528 participants

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

Melt Pharmaceuticals

NCT06383273

Recruiting Phase 3 520 participants

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Merck Sharp & Dohme

NCT06305754

Recruiting Phase 3 500 participants

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

Imunon

NCT06915025

Recruiting Phase 3 500 participants

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Revolution Medicines

NCT07252232

Recruiting 500 participants

Pounce™ Thrombectomy System Retrospective Registry

SurModics

NCT05868161

Recruiting Phase 1 479 participants

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

Amgen

NCT04221542

Recruiting Phase 3 466 participants

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

Incyte Corporation

NCT07214779

Recruiting Phase 3 460 participants

A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer

AbbVie

NCT06614192

Recruiting Phase 1 450 participants

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Merck Sharp & Dohme

NCT04165070

Recruiting Phase 3 412 participants

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

Rakuten Medical

NCT06699212

Recruiting Phase 3 396 participants

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

Takeda

NCT06227910

Recruiting Phase 1 380 participants

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Amgen

NCT07037758

Recruiting Phase 1 370 participants

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Merck Sharp & Dohme

NCT02332668

Recruiting Phase 1 319 participants

A Study of XMT-1660 in Participants With Solid Tumors

Mersana Therapeutics

NCT05377996

Recruiting Phase 1 315 participants

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT07160725

Recruiting 300 participants

Perform Humeral System Study

Stryker Trauma and Extremities

NCT05067543

Recruiting Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

Recruiting Phase 2 222 participants

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Eli Lilly and Company

NCT07223840

Recruiting Phase 2 220 participants

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

Regeneron Pharmaceuticals

NCT06787612

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Recruiting status is reported by each study's sponsor and mirrored from the public registry. Always confirm current eligibility and status on ClinicalTrials.gov before contacting a study.

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