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RECRUITING Phase 2

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

NCT06787612 · View on ClinicalTrials.gov ↗

Study Summary

This study is researching an experimental drug called ubamatamab, also referred to as "study drug". The study is focused on patients who have advanced ovarian cancer. The aim of the study is to see how safe, tolerable, and effective the study drug is on its own and in combination with other anti-cancer drugs (bevacizumab, cemiplimab, fianlimab and a standard chemotherapy drug, pegylated liposomal doxorubicin \[PLD\]), referred to as "combination drugs'. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug and its experimental combinations * How much study drug and fianlimab is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) and its combinations

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Cemiplimab
  • DRUG PLD
  • DRUG Ubamatamab
  • DRUG Fianlimab

Study Locations (20)

Florida

  • Mayo Clinic Jacksonville — Jacksonville
  • University of Miami Sylvester Comprehensive Cancer Center — Miami
  • Tampa General Hospital Cancer Institute — Tampa

California

  • UC San Diego Health — La Jolla
  • Cedars Sinai Medical Center — Los Angeles

Gyeonggi-do

  • National Cancer Center — Gyeonggi-do
  • Seoul National University Bundang Hospital — Seongnam-si

Alabama

  • The University of Alabama at Birmingham — Birmingham

Illinois

  • University of Chicago — Chicago

Kansas

  • The University of Kansas Cancer Center — Westwood

Kentucky

  • Norton Cancer Institute, St. Matthews Clinic — Louisville

Massachusetts

  • Massachusetts General Hospital — Boston

Trial Details

FieldValue
Enrollment Target 220 participants
Start Date 2025-05-28
Est. Completion 2028-12-07
Phase Phase 2

Sponsor

Regeneron Pharmaceuticals

290 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06787612

The ClinicalTrials.gov registry entry for NCT06787612 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 220 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Regeneron Pharmaceuticals, which has 290 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ovarian Cancer appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06787612 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Florida, California, Gyeonggi-do. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06787612 about?

NCT06787612 is a clinical study titled "Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer". This study is researching an experimental drug called ubamatamab, also referred to as "study drug". The study is focused on patients who have advanced ovarian cancer. The aim of the study is to see how safe, tolerable, and effective the study drug is on its own and in combination with other anti-ca...

What is the current status of trial NCT06787612?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 220 participants. The study started on 2025-05-28. Estimated completion is 2028-12-07.

What conditions does trial NCT06787612 study?

This clinical trial studies the following conditions: Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06787612?

The interventions under investigation include: Bevacizumab (DRUG), Cemiplimab (DRUG), PLD (DRUG), Ubamatamab (DRUG), Fianlimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06787612?

This trial is sponsored by Regeneron Pharmaceuticals, which has 290 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06787612 being conducted?

This trial has 20 study locations across Alabama, California, Florida, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial