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ClinicalTrials.gov official registry

X-Linked Retinitis Pigmentosa clinical trials

All 9 indexed X-Linked Retinitis Pigmentosa trials have closed enrollment.

9 US clinical trials ·

X-Linked Retinitis Pigmentosa is the subject of 9 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 2 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Janssen Research & Development, running 4 of these trials.

The research picture

X-Linked Retinitis Pigmentosa has 9 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
4
top sponsor: Janssen Research & Development
Phase 13Phase 23Phase 32

Active & Recent Trials

9 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 3 97 participants

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

Janssen Research & Development

NCT04794101

ACTIVE NOT RECRUITING Phase 2 85 participants

A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP

Beacon Therapeutics

NCT04850118

ACTIVE NOT RECRUITING Phase 1 29 participants

Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations

Beacon Therapeutics

NCT03316560

ACTIVE NOT RECRUITING Phase 2 24 participants

A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

Janssen Research & Development

NCT06646289

ACTIVE NOT RECRUITING Phase 1 21 participants

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

4D Molecular Therapeutics

NCT04517149

ACTIVE NOT RECRUITING Phase 2 14 participants

A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)

Beacon Therapeutics

NCT06333249

COMPLETED Phase 3 105 participants

Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

Janssen Research & Development

NCT04671433

COMPLETED Phase 1 50 participants

A Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa Using BIIB112

Biogen

NCT03116113

COMPLETED 42 participants

Long-term Follow-up Gene Therapy Study for RPGR- XLRP

Janssen Research & Development

NCT04312672

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 3
Phase 3 2

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the X-Linked Retinitis Pigmentosa Trial Landscape

9 indexed X-Linked Retinitis Pigmentosa studies · 0 recruiting (0%).

Phase mix: 2 late (III/IV) vs 6 early (I/II).

Top sponsor: Janssen Research & Development (4 trials), 3 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for X-Linked Retinitis Pigmentosa?

PlainTrial tracks 9 US clinical trials for X-Linked Retinitis Pigmentosa, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for X-Linked Retinitis Pigmentosa?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.