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NCT06333249 · ClinicalTrials.gov registry record · Phase 2
A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)
A Phase 2 study of X-Linked Retinitis Pigmentosa, sponsored by Beacon Therapeutics.
- Active
- Registry status
- Phase 2
- Development phase
- 14
- Enrollment target
- 6
- Study locations
NCT06333249 is a Phase 2 study of X-Linked Retinitis Pigmentosa that is active but no longer recruiting, run by Beacon Therapeutics. The registered enrollment target is 14 participants, below the 57-participant average among 8 other X-Linked Retinitis Pigmentosa trials with a reported enrollment target (75% lower). The trial reports 6 study locations across 5 states.
The verdict
NCT06333249, a Phase 2 study of X-Linked Retinitis Pigmentosa, is active but no longer recruiting, sponsored by Beacon Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 14 participants
- Enrollment target
- 6
- Study locations
Study Summary
This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retinitis pigmentosa caused by RPGR mutations.
Conditions Studied
Interventions
- BIOLOGICAL rAAV2tYF-GRK1-RPGR
Study Locations (6)
Ohio
- Cincinnati Eye Institute - Cincinnati
- Cleveland Clinic - Cleveland
Florida
- University of Florida - Jacksonville
Massachusetts
- Boston Children's Hosptial - Boston
Oregon
- Casey Eye Institute - Portland
Texas
- Retina Foundation of the Southwest - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2021-04-13 |
| Est. Completion | 2027-02 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06333249
The ClinicalTrials.gov registry entry for NCT06333249 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 57-participant average among 8 other X-Linked Retinitis Pigmentosa trials with a reported enrollment target (75% lower). The listed sponsor is Beacon Therapeutics, which has 12 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with X-Linked Retinitis Pigmentosa appearing as the primary indexed condition, and to 1 intervention - of which rAAV2tYF-GRK1-RPGR is the first listed.
NCT06333249 reports 6 study locations spanning 5 distinct geographic areas - top geographies include Ohio, Florida, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06333249 about?
NCT06333249 is a clinical study titled "A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)". This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retinitis pigmentosa caused by RPGR mutations.
What is the current status of trial NCT06333249?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 14 participants. The study started on 2021-04-13. Estimated completion is 2027-02.
What conditions does trial NCT06333249 study?
This clinical trial studies the following conditions: X-Linked Retinitis Pigmentosa.
What interventions are being tested in trial NCT06333249?
The interventions under investigation include: rAAV2tYF-GRK1-RPGR (BIOLOGICAL).
Who is sponsoring clinical trial NCT06333249?
This trial is sponsored by Beacon Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06333249 being conducted?
This trial has 6 study locations across Florida, Massachusetts, Ohio, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for X-Linked Retinitis Pigmentosa
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
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A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)
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A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP
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Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
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-
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
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COMPLETED
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.