Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Wrinkle: early-phase trial registry
6 of 26 indexed Wrinkle trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #627 of 28,707 conditions by registered trial count.
26 US clinical trials · 6 currently recruiting · #627 of 28,707 conditions by registered trial count
Wrinkle: 26 US clinical trials tracked, 6 recruiting.
Wrinkle is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Revision Skincare, running 4 of these trials.
Enrollment posture brief
Registry condition wrinkle
OPEN 6 | RECR 23% | LATE 1 | EARLY 2 | RANK #627 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Actinic Keratoses (23% recruiting · 13 trials)
Wrinkle lists 6 open slots (23% of 26 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Wrinkle on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Wrinkle is recruiting below its size-band peers.
6 of 26 indexed trials (23.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Wrinkle research.
Revision Skincare accounts for 4 of 26 trials (15.4%). 16 distinct sponsors appear on at least one study for this condition label.
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Most Wrinkle trials plan to enrol fewer than 100 people.
Median target enrolment is 44 among the 26 trials that report a genuine target (sentinel values excluded). 18 of those (69.2%) plan for fewer than 100 participants.
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Wrinkle research is mostly interventional.
25 interventional and 1 observational studies make up this index (96.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
26 total, page 1 of 1
Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation
Global Aesthetics
NCT06385171
AVAVA MIRIA General Use
AVAVA
NCT06868615
A Prospective Controlled Study to Evaluate the Safety and Effectiveness of Thermage® FLX Radiofrequency Treatment
Bausch Health Americas
NCT07187297
The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Integrative Skin Science and Research
NCT06571721
The Effects of Almond on Facial Skin Collagen and Wrinkles
Integrative Skin Science and Research
NCT06074276
Feasibility Study to Collect and Assess Safety Data for a Radiofrequency Microneedling Device for Electrocoagulation and Hemostasis of Soft Tissues for Dermatologic Conditions
Cynosure
NCT05987319
Clinical Study to Evaluate the Safety and Efficacy of Candela Technology
Candela Corporation
NCT06202274
Clinical Feasibility Study to Evaluate the Safety and Performance of the Profound Matrix System
Candela Corporation
NCT06157567
AV-23-001 AVAVA MIRIA Pilot Study
AVAVA
NCT06557434
A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions
Krystal Biotech
NCT04540900
Restylane Refyne for Correction of Horizontal Neck Rhytides
Siperstein Dermatology
NCT04162496
Functional Usability and Feasibility Testing of the Profound Matrix™ System
Candela Corporation
NCT06192550
Open Label Extension for 43USSA1812
Galderma R&D
NCT04595331
An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream
Revision Skincare
NCT04911374
Comparison of the Cosmetic Effects of Bakuchiol and Retinol
University of California, Davis
NCT03112863
A 12 Week Study to Evaluate the Efficacy of an Eye Cream
Revision Skincare
NCT05807620
An Exploratory Investigation of a Novel Skincare Regimen
Trophy Skin
NCT05517720
Fractional CO2 Laser System (Fraxel Repair Laser) Intended for Treatment of Perioral Rhytides/Wrinkles
University of Texas Southwestern Medical Center
NCT03715049
Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity
Cytrellis Biosystems
NCT03228641
Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles
Vitality Institute Medical Products
NCT05162300
A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum
Revision Skincare
NCT05271136
Post Market Usability Evaluation Of The PicoSure Pro Device
Cynosure
NCT05102617
Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles
Venus Concept
NCT03831477
Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofrequency Microneedling for Facial Rejuvenation
Revision Skincare
NCT06157853
Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles
Venus Concept
NCT04057768
Open Label Study Exploring Tissue Histopathology After Ellacor® Procedure in an Abdominoplasty Model.
Cytrellis Biosystems
NCT06421207
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Wrinkle records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Wrinkle trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Wrinkle page
26 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 6 Wrinkle trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Revision Skincare sponsors the most Wrinkle trials on record, review their full trial history before evaluating a specific study. See Revision Skincare's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Wrinkle condition card totals 26 registered trials; most-linked intervention Facial Moisturizer; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.