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ClinicalTrials.gov 12 recruiting now early-phase tilt

Weight Gain: early-phase trial registry

12 of 39 indexed Weight Gain trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #382 of 28,707 conditions by registered trial count.

39 US clinical trials · 12 currently recruiting · #382 of 28,707 conditions by registered trial count

Weight Gain: 39 US clinical trials tracked, 12 recruiting.

Weight Gain is the subject of 39 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 3 of these trials.

Enrollment posture brief

Registry condition weight-gain

OPEN 12 | RECR 31% | LATE 1 | EARLY 6 | RANK #382 | SPON 3

Nearest open-share peer: Accidental Falls (31% recruiting · 13 trials)

B-cell Lymphoma46.2%Binge-Eating Disorder43.6%Kidney Diseases38.5%Weight Gain (this)31%Acute Myelogenous Leukemia17.9%
Open-enrollment share among volume-matched conditions near Weight Gain

Weight Gain lists 12 open slots (31% of 39 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Weight Gain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Weight Gain is recruiting below its size-band peers.

    12 of 39 indexed trials (30.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Weight Gain trials is spread across many organizations.

    University of Michigan accounts for 3 of 39 trials (7.7%). 30 distinct sponsors appear on at least one study for this condition label.

  3. Typical Weight Gain enrolment sits around 96 participants.

    Median target enrolment is 96 among the 39 trials that report a genuine target (sentinel values excluded). 20 of those (51.3%) plan for fewer than 100 participants.

  4. Weight Gain research is mostly interventional.

    34 interventional and 5 observational studies make up this index (87.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 24Phase 31

Open and recent trials

39 total, page 1 of 1

RECRUITING NA 570 participants

Grocery Delivery and Healthy Weight Gain Among Low-income Pregnant Young Women

University of Michigan

NCT05000645

RECRUITING NA 360 participants

Testing Responses of Young Adults to Intervention Messages for Promoting Physical Activity Trial

University of Michigan

NCT05794178

RECRUITING Phase 3 300 participants

A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)

Eli Lilly and Company

NCT06439277

RECRUITING NA 250 participants

The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer

Johns Hopkins University

NCT05780814

RECRUITING NA 150 participants

The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)

Arkansas Children's Hospital Research Institute

NCT05992688

RECRUITING Phase 2 144 participants

A Novel Obesity Prevention Program for High-Risk Infants in Primary Care

Children's Hospital Medical Center, Cincinnati

NCT06028113

RECRUITING Phase 2 120 participants

Early Metabolic Effects of Dolutegravir or Tenofovir Alefenamide in Healthy Volunteers

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05652478

RECRUITING NA 110 participants

Time Restricted Eating for WeIght LoSs MainTenance-2

NYU Langone Health

NCT07190170

RECRUITING NA 46 participants

Exercise Effects on Adipose Tissue Structure and Function

University of Michigan

NCT04812314

RECRUITING Phase 2 30 participants

Incretin Microdosing for Cardiometabolic Health in People With HIV

The University of Texas Health Science Center, Houston

NCT07325500

RECRUITING NA 20 participants

Sleep and Metabolism

Oregon Health and Science University

NCT05775627

RECRUITING NA 15 participants

Exercise, Brain Activity, and Weight Maintenance

Joslin Diabetes Center

NCT06511310

ACTIVE NOT RECRUITING NA 70 participants

Comparing Reduction With ESD- Versus APC-TORe

Stephen Firkins

NCT06131281

COMPLETED NA 2,184 participants

Effects of Sugary Drinks Counter-marketing Messages

Stanford University

NCT05953194

COMPLETED NA 1,067 participants

Implementing Effective, Collaborative Care for Schizophrenia (EQUIP-2)

VA Office of Research and Development

NCT00137280

COMPLETED NA 599 participants

Study of Novel Approaches for Prevention

Wake Forest University

NCT01183689

COMPLETED NA 489 participants

The GEM (Goals for Eating and Moving) Study

NYU Langone Health

NCT03006328

COMPLETED NA 430 participants

Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)

University of Tennessee

NCT03057808

COMPLETED NA 281 participants

Maternal-Offspring Metabolics:Family Intervention Trial

Northwestern University

NCT01631747

COMPLETED NA 176 participants

Whole Body Vibration Training for Healthy Body Composition in Young Adults

Oregon Health and Science University

NCT02134275

COMPLETED NA 160 participants

Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment

University of North Carolina, Chapel Hill

NCT03490734

COMPLETED NA 142 participants

Healthy Motivations for Moms-to-be Study

University of South Carolina

NCT03063528

COMPLETED 110 participants

Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen

Thomas Jefferson University

NCT03646370

COMPLETED 100 participants

The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00072917

COMPLETED Phase 1 96 participants

Reducing Antipsychotic-Induced Weight Gain in Children With Metformin

Nationwide Children's Hospital

NCT01231074

COMPLETED NA 55 participants

Cardiovascular Health in Postpartum Women Diagnosed With Excessive Gestational Weight Gain

Stanford University

NCT02142452

COMPLETED NA 52 participants

Weight Gain Prevention

The Miriam Hospital

NCT00606840

COMPLETED NA 48 participants

Eating Mindfully to Prevent Weight Regain

University of Utah

NCT04847843

COMPLETED NA 44 participants

Effect of Milk Warming on the Very Low Birth Weight Infant

University of Oklahoma

NCT04282655

COMPLETED NA 33 participants

Development of Fluid Intake App for Management of Fluid Intake During Hemodialysis , Full Scale Trial

Wake Forest University Health Sciences

NCT04194164

COMPLETED NA 32 participants

Body Composition Changes During Overfeeding Plus Resistance Training

Texas Tech University

NCT04069351

COMPLETED 27 participants

Role Of Metabolic Adaptation In Weight Regain

Pennington Biomedical Research Center

NCT05766358

COMPLETED NA 23 participants

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

Stanford University

NCT03935854

COMPLETED Phase 1 20 participants

Lorcaserin for Preventing Weight Gain Among Smokers

Mayo Clinic

NCT02393547

COMPLETED NA 18 participants

Preventing Weight Gain in African American Reproductive-Aged Women

Washington University School of Medicine

NCT02416921

COMPLETED NA 18 participants

A Trial of Lifestyle Interventions to Control Weight After Bariatric Surgery

Beth Israel Deaconess Medical Center

NCT02603601

COMPLETED 15 participants

Effects of Antipsychotic Medications on Energy Intake and Expenditure

Washington University School of Medicine

NCT00836251

COMPLETED Phase 2 9 participants

Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth

University of North Carolina, Chapel Hill

NCT00617240

COMPLETED 4 participants

Horton & Maizy Pilot Study for Resistant to Starch

Pennington Biomedical Research Center

NCT01338571

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4
Phase 3 1

Named interventions

Most-linked intervention names on Weight Gain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Tirzepatide Drug
2 trials
Standard lifestyle intervention Behavioral
1 trials
Mind-body lifestyle intervention Behavioral
1 trials
Intensive lifestyle change therapy Behavioral
1 trials
Lifestyle Intervention Group Behavioral
1 trials
Exposure to control (neutral) messages Behavioral
1 trials
Exposure to traditional health messages Behavioral
1 trials
Exposure to counter-marketing messages Behavioral
1 trials

US sites by state

Facility locations filed on Weight Gain trials. A trial with sites in several states counts in each.

Texas 5 trials
California 5 trials
New York 4 trials
North Carolina 4 trials
Ohio 3 trials
Michigan 3 trials
Louisiana 3 trials
Utah 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Weight Gain page

39 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Weight Gain condition card totals 39 registered trials; most-linked intervention Tirzepatide; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.