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NCT07325500 · ClinicalTrials.gov registry record · Phase 2
Incretin Microdosing for Cardiometabolic Health in People With HIV
A Phase 2 study of Weight Gain, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07325500: Recruiting Phase 2 study of Weight Gain, sponsored by The University of Texas Health Science Center, Houston.
NCT07325500 is a Phase 2 study of Weight Gain that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 30 participants, below the 221-participant average among 38 other Weight Gain trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07325500, a Phase 2 study of Weight Gain, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The objectives of this study are as follows: Primary Objective * To determine the rate of weight regain in people living with human immunodeficiency virus (HIV) (PWH) receiving semaglutide microdosing vs. no additional drug following induction therapy. Secondary Objectives * To evaluate the tolerability of semaglutide microdosing in adults with HIV. * To evaluate changes in weight, waist circumference (WC) and body mass index (BMI) over 12 weeks (W) of semaglutide weight loss induction and 48 W of semaglutide microdosing therapy.
Primary Outcome
The percent weight regain from weeks 12-60 (microdosing period), calculated as the median within-person: change in weight (kg) from weeks 60-12 (microdosing period) divided by the change in weight (kg) from weeks 12-0 (dose escalation period).
Conditions Studied
Interventions
- DRUG Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly
- DRUG Dose escalation to 2 mg semaglutide weekly then no semaglutide
Study Locations (1)
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-02-12 |
| Est. Completion | 2029-06-30 |
| Phase | Phase 2 |
What NCT07325500 shows while recruiting
NCT07325500 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 221-participant average among 38 other Weight Gain trials with a reported enrollment target (86% lower).
The record links to 1 condition, with Weight Gain appearing as the primary indexed condition, and to 2 interventions - of which Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly is the first listed.
NCT07325500 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT07325500 about?
NCT07325500 is a clinical study titled "Incretin Microdosing for Cardiometabolic Health in People With HIV". The objectives of this study are as follows: Primary Objective * To determine the rate of weight regain in people living with human immunodeficiency virus (HIV) (PWH) receiving semaglutide microdosing vs. no additional drug following induction therapy. Secondary Objectives * To evaluate the tole...
What is the current status of trial NCT07325500?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2026-02-12. Estimated completion is 2029-06-30.
What conditions does trial NCT07325500 study?
This clinical trial studies the following conditions: Weight Gain.
What interventions are being tested in trial NCT07325500?
The interventions under investigation include: Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly (DRUG), Dose escalation to 2 mg semaglutide weekly then no semaglutide (DRUG).
Who is sponsoring clinical trial NCT07325500?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07325500 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07325500's enrollment target sits among peer trials
30 29th of 38 higher than 10 of 38 other Weight Gain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Weight Gain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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