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ClinicalTrials.gov 10 recruiting now official registry

Systemic Lupus Erythematosus (SLE) clinical trials

10 of 15 indexed Systemic Lupus Erythematosus (SLE) trials are currently recruiting.

15 US clinical trials · 10 currently recruiting

Systemic Lupus Erythematosus (SLE) is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Bristol-Myers Squibb, running 2 of these trials.

The research picture

Systemic Lupus Erythematosus (SLE) has 15 registered US clinical trials, 10 of them open to new participants right now, about 67% of the total.

10
recruiting participants now
67%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Bristol-Myers Squibb
Phase 15Phase 23Phase 42

Active & Recent Trials

15 total, page 1 of 1

RECRUITING 10,000 participants

Research Accelerated by You Lupus Registry

Lupus Foundation of America

NCT06927219

RECRUITING 3,500 participants

Lupus Landmark Study: A Prospective Registry and Biorepository

Lupus Research Alliance

NCT05934149

RECRUITING Phase 1 244 participants

A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease

Fate Therapeutics

NCT06308978

RECRUITING 223 participants

A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

Bristol-Myers Squibb

NCT07175285

RECRUITING Phase 1 148 participants

A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE Participants

DualityBio

NCT06625671

RECRUITING 100 participants

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT05567198

RECRUITING Phase 1 78 participants

Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus

National Heart, Lung, and Blood Institute (NHLBI)

NCT06032923

RECRUITING Phase 4 35 participants

A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132

Bristol-Myers Squibb

NCT06875960

RECRUITING Phase 1 24 participants

CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

Children's Hospital of Philadelphia

NCT06839976

RECRUITING Phase 1 10 participants

UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients

LiveKidney.Bio

NCT06737380

ACTIVE NOT RECRUITING Phase 2 6 participants

Descartes-08 for Patients With Systemic Lupus Erythematosus

Cartesian Therapeutics

NCT06038474

COMPLETED Phase 2 244 participants

Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

Amgen

NCT04058028

COMPLETED Phase 2 182 participants

A Phase 2 Efficacy and Safety Study of Dapirolizumab Pegol (DZP) in Systemic Lupus Erythematosus

UCB Biopharma S.P.R.L.

NCT02804763

COMPLETED NA 75 participants

CCCR Lupus Patient Navigator Program

Medical University of South Carolina

NCT04461158

COMPLETED Phase 4 38 participants

Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Active Disease

Mallinckrodt

NCT01753401

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Systemic Lupus Erythematosus (SLE) Trial Landscape

15 indexed Systemic Lupus Erythematosus (SLE) studies · 10 recruiting (67%).

Phase mix: 2 late (III/IV) vs 8 early (I/II).

Top sponsor: Bristol-Myers Squibb (2 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Systemic Lupus Erythematosus (SLE)?

PlainTrial tracks 15 US clinical trials for Systemic Lupus Erythematosus (SLE), of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Systemic Lupus Erythematosus (SLE)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.