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Substance Use Disorder (SUD) clinical trials
Every US clinical trial registered for Substance Use Disorder (SUD) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
16 US clinical trials · 15 currently recruiting
The research picture
Substance Use Disorder (SUD) has 16 registered US clinical trials, 15 of them open to new participants right now — about 94% of the total.
- 15
- recruiting participants now
- 94%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 3
- top sponsor: University of California, San Francis
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Pathways to Perinatal Mental Health Equity
University of Massachusetts, Worcester
NCT06790641
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
University of Arkansas
NCT06923423
Calls and Coordination for Transitions of Care at Re-entry
University of Wisconsin, Madison
NCT06794983
California MEPS Hub
University of California, Los Angeles
NCT07433985
The Trans-Led Care Study
Illinois Institute of Technology
NCT06880705
Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
Icahn School of Medicine at Mount Sinai
NCT07318480
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
Massachusetts General Hospital
NCT07199335
Adolescent Stress and Substance Intervention Subsequent to Trauma
Rhode Island Hospital
NCT07197476
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
NCT06442423
WORTH Paths Intervention
Fairleigh Dickinson University
NCT06889831
Wellness, Intervention Strategies and HIV Care
University of California, San Francis
NCT07069374
Substance Use in Pregnant People - Optimizing Retention in Treatment
Washington University School of Medicine
NCT07104123
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
University of California, San Francis
NCT06678672
Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.
Medical College of Wisconsin
NCT06617949
Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder
University of California, San Francis
NCT07214467
Addressing Barriers to Care for Substance Use Disorder Trial
Kaiser Permanente
NCT06729957
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Substance Use Disorder (SUD) Trial Landscape
ClinicalTrials.gov lists 16 US studies indexed under Substance Use Disorder (SUD), and 15 of those are currently open to recruitment — roughly 94% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Substance Use Disorder (SUD) shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Substance Use Disorder (SUD) is led by University of California, San Francis with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Substance Use Disorder (SUD)?
PlainTrial tracks 16 US clinical trials for Substance Use Disorder (SUD), of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Substance Use Disorder (SUD)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.