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ClinicalTrials.gov 15 recruiting now official registry

Substance Use Disorder (SUD) clinical trials

15 of 16 indexed Substance Use Disorder (SUD) trials are currently recruiting.

16 US clinical trials · 15 currently recruiting

Substance Use Disorder (SUD) is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 3 of these trials.

The research picture

Substance Use Disorder (SUD) has 16 registered US clinical trials, 15 of them open to new participants right now, about 94% of the total.

15
recruiting participants now
94%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: University of California, San Francisco
Phase 12Phase 41

Active & Recent Trials

16 total, page 1 of 1

RECRUITING NA 1,270 participants

Pathways to Perinatal Mental Health Equity

University of Massachusetts, Worcester

NCT06790641

RECRUITING NA 640 participants

Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

University of Arkansas

NCT06923423

RECRUITING NA 488 participants

Calls and Coordination for Transitions of Care at Re-entry

University of Wisconsin, Madison

NCT06794983

RECRUITING NA 318 participants

California MEPS Hub

University of California, Los Angeles

NCT07433985

RECRUITING NA 124 participants

The Trans-Led Care Study

Illinois Institute of Technology

NCT06880705

RECRUITING NA 120 participants

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

Icahn School of Medicine at Mount Sinai

NCT07318480

RECRUITING Phase 4 100 participants

Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

Massachusetts General Hospital

NCT07199335

RECRUITING NA 62 participants

Adolescent Stress and Substance Intervention Subsequent to Trauma

Rhode Island Hospital

NCT07197476

RECRUITING Phase 1 50 participants

Open-Label Psilocybin Study in Transdiagnostic Population

Yale University

NCT06442423

RECRUITING NA 50 participants

WORTH Paths Intervention

Fairleigh Dickinson University

NCT06889831

RECRUITING NA 50 participants

Wellness, Intervention Strategies and HIV Care

University of California, San Francisco

NCT07069374

RECRUITING NA 40 participants

Substance Use in Pregnant People - Optimizing Retention in Treatment

Washington University School of Medicine

NCT07104123

RECRUITING NA 36 participants

Contingency Management for Veteran Smokers Undergoing Major Elective Surgery

University of California, San Francisco

NCT06678672

RECRUITING Early Phase 1 20 participants

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

Medical College of Wisconsin

NCT06617949

RECRUITING NA 6 participants

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

University of California, San Francisco

NCT07214467

ACTIVE NOT RECRUITING NA 360 participants

Addressing Barriers to Care for Substance Use Disorder Trial

Kaiser Permanente

NCT06729957

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Substance Use Disorder (SUD) Trial Landscape

16 indexed Substance Use Disorder (SUD) studies · 15 recruiting (94%).

Phase mix: 1 late (III/IV) vs 2 early (I/II).

Top sponsor: University of California, San Francisco (3 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Substance Use Disorder (SUD)?

PlainTrial tracks 16 US clinical trials for Substance Use Disorder (SUD), of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Substance Use Disorder (SUD)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.