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NCT07433985 · ClinicalTrials.gov registry record · NA

California MEPS Hub

A NA study of HIV Prevention and Substance Use Disorder (SUD), sponsored by University of California, Los Angeles.

Recruiting
Registry status
NA
Development phase
318
Enrollment target
3
Study locations

NCT07433985: Recruiting NA study of HIV Prevention and Substance Use Disorder (SUD), sponsored by University of California, Los Angeles.

NCT07433985 is a NA study of HIV Prevention and Substance Use Disorder (SUD) that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 318 participants, below the 372-participant average among 32 other HIV Prevention trials with a reported enrollment target (15% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07433985, a NA study of HIV Prevention and Substance Use Disorder (SUD), is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
NA
Development phase
318 participants
Enrollment target
3
Study locations

Study Summary

The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?" The Mobile Enhanced Prevention Support (MEPS) intervention was originally implemented in Los Angeles County and was proven successful in promoting biomedical HIV prevention (PrEP) uptake and preventative screenings in people who used drugs who recently left incarceration. MEPS is an evidence-based intervention for people with substance use disorders (SUD) that incorporates a client-centered planning session, including trained peer mentors, service utilization incentives, and a mobile application (GeoPass). The study includes a randomized controlled trial (RCT) across three community partners located in Riverside and Alameda Counties. At least 300 people will be enrolled in these three counties; the first 200 will be randomized to either receive the intervention or usual care, with the final 100 all receiving the intervention. The primary implementation outcome for the study involves using an implementation science framework and assessment tools to examine MEPS's implementation. Key outcomes include how well the implementation strategies used support intervention enrollment and retention, integration with existing services in each partnering community agency, and perceived intervention acceptability, feasibility, appropriateness, and maintenance at 6- and 12-months. The primary effectiveness outcome for the study is an increase in HIV testing, PrEP uptake and adherence, and SUD service utilization at 6 months and 12 months in the MEPS compared to the usual care group. Secondary effectiveness outcomes include frequency of service use for SUDs, hepatitis C virus testing, and linkage to care for those who test positive for HIV or hepatitis C.

Primary Outcome

Defined as the participant obtaining a prescription for PrEP and self-reporting taking the medication

Conditions Studied

HIV Prevention Substance Use Disorder (SUD) Preexposure Prophylaxis (PrEP) Incarceration Sexually Transmitted Infections (STI) Hepatitis C Virus (HCV)

Interventions

  • OTHER Control
  • BEHAVIORAL Mobile Enhanced Prevention Support (MEPS)

Study Locations (3)

California

  • CAL-PEP - Oakland
  • Kindful Restoration - Riverside
  • Starting Over, Inc - Riverside

Trial Details

FieldValue
Enrollment Target 318 participants
Start Date 2025-12-01
Est. Completion 2029-07-31
Phase NA
University of California, Los Angeles

897 total trials

What NCT07433985 shows while recruiting

NCT07433985 is an interventional study that assigns participants to a tested intervention. The registered 318 participants enrollment target is mid-sized for trials with a published cap, below the 372-participant average among 32 other HIV Prevention trials with a reported enrollment target (15% lower).

The record links to 6 conditions, with HIV Prevention appearing as the primary indexed condition, and to 2 interventions - of which Control is the first listed.

NCT07433985 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT07433985 about?

NCT07433985 is a clinical study titled "California MEPS Hub". The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?" The Mobile Enhanced Prevention Support (MEPS) interven...

What is the current status of trial NCT07433985?

This trial is currently recruiting. It is a NA study. The enrollment target is 318 participants. The study started on 2025-12-01. Estimated completion is 2029-07-31.

What conditions does trial NCT07433985 study?

This clinical trial studies the following conditions: HIV Prevention, Substance Use Disorder (SUD), Preexposure Prophylaxis (PrEP), Incarceration, Sexually Transmitted Infections (STI).

What interventions are being tested in trial NCT07433985?

The interventions under investigation include: Control (OTHER), Mobile Enhanced Prevention Support (MEPS) (BEHAVIORAL).

Who is sponsoring clinical trial NCT07433985?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07433985 being conducted?

This trial has 3 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for HIV Prevention

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07433985's enrollment target sits among peer trials

318 8th of 32 higher than 25 of 32 other HIV Prevention trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other HIV Prevention trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT07433985

Source: ClinicalTrials.gov NCT07433985, the US trial registry maintained by the National Library of Medicine. NCT07433985 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.