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ClinicalTrials.gov 6 recruiting now early-phase tilt

Stage IIIC Lung Cancer AJCC v8: early-phase trial registry

6 of 23 indexed Stage IIIC Lung Cancer AJCC v8 trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #724 of 28,707 conditions by registered trial count.

23 US clinical trials · 6 currently recruiting · #724 of 28,707 conditions by registered trial count

Stage IIIC Lung Cancer AJCC v8: 23 US clinical trials tracked, 6 recruiting.

Stage IIIC Lung Cancer AJCC v8 is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

Enrollment posture brief

Registry condition stage-iiic-lung-cancer-ajcc-v8

OPEN 6 | RECR 26% | LATE 3 | EARLY 16 | RANK #724 | SPON 7

Nearest open-share peer: Parkinson's Disease (26% recruiting · 161 trials)

Breast Cancer Stage II47.8%Advanced Non-Small-Cell Lung39.1%Anxiety Disorder30.4%Barrett's Esophagus26.1%Stage IIIC Lung Cancer A (th…26%
Open-enrollment share among volume-matched conditions near Stage IIIC Lung Cancer AJCC v8

Stage IIIC Lung Cancer AJCC v8 lists 6 open slots (26% of 23 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Stage IIIC Lung Cancer AJCC v8 on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Stage IIIC Lung Cancer AJCC v8 is recruiting below its size-band peers.

    6 of 23 indexed trials (26.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Stage IIIC Lung Cancer AJCC v8 research.

    M.D. Anderson Cancer Center accounts for 7 of 23 trials (30.4%). 11 distinct sponsors appear on at least one study for this condition label.

  3. Most Stage IIIC Lung Cancer AJCC v8 trials plan to enrol fewer than 100 people.

    Median target enrolment is 38 among the 23 trials that report a genuine target (sentinel values excluded). 19 of those (82.6%) plan for fewer than 100 participants.

  4. Stage IIIC Lung Cancer AJCC v8 research is mostly interventional.

    23 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 110Phase 26Phase 33

Open and recent trials

23 total, page 1 of 1

RECRUITING Phase 3 304 participants

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

National Cancer Institute (NCI)

NCT06096844

RECRUITING NA 100 participants

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

M.D. Anderson Cancer Center

NCT05010109

RECRUITING Phase 2 51 participants

Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy

M.D. Anderson Cancer Center

NCT04892953

RECRUITING NA 34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Rutgers, The State University of New Jersey

NCT04751747

RECRUITING Phase 2 30 participants

SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer

University of Washington

NCT05570825

RECRUITING Phase 1 28 participants

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT05136846

ACTIVE NOT RECRUITING Phase 3 660 participants

Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04092283

ACTIVE NOT RECRUITING Phase 3 600 participants

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03793179

ACTIVE NOT RECRUITING Phase 2 82 participants

Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT05096663

ACTIVE NOT RECRUITING Phase 1 59 participants

Niraparib, Temozolomide and Atezolizumab in Treating Patients With Advanced Solid Tumors and Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy

Jonsson Comprehensive Cancer Center

NCT03830918

ACTIVE NOT RECRUITING Phase 1 51 participants

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Roswell Park Cancer Institute

NCT02955290

ACTIVE NOT RECRUITING Phase 1 50 participants

Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04073745

ACTIVE NOT RECRUITING Phase 2 48 participants

Niraparib and Dostarlimab for the Treatment of Small Cell Lung Cancer and Other High-Grade Neuroendocrine Carcinomas

M.D. Anderson Cancer Center

NCT04701307

ACTIVE NOT RECRUITING NA 42 participants

A Nurse-Led Intervention for Fear of Progression in Advanced Cancer

City of Hope Medical Center

NCT04819997

ACTIVE NOT RECRUITING Phase 1 37 participants

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

M.D. Anderson Cancer Center

NCT03225664

ACTIVE NOT RECRUITING Phase 1 32 participants

Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT05017025

ACTIVE NOT RECRUITING Phase 2 25 participants

Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03637816

ACTIVE NOT RECRUITING Phase 1 12 participants

Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04837716

ACTIVE NOT RECRUITING Phase 1 8 participants

Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer

City of Hope Medical Center

NCT05166616

ACTIVE NOT RECRUITING Phase 1 6 participants

Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

University of California, Irvine

NCT05334329

ACTIVE NOT RECRUITING Phase 1 5 participants

Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC

City of Hope Medical Center

NCT04227028

ACTIVE NOT RECRUITING Phase 2 5 participants

Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer

University of Southern California

NCT05340309

COMPLETED NA 38 participants

Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer

City of Hope Medical Center

NCT03776253

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 6
Phase 3 3

Named interventions

Most-linked intervention names on Stage IIIC Lung Cancer AJCC v8 records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Carboplatin Drug
6 trials
Computed Tomography Procedure
5 trials
Questionnaire Administration Other
4 trials
Biospecimen Collection Procedure
4 trials
Paclitaxel Drug
3 trials
Durvalumab Biological
3 trials
Magnetic Resonance Imaging Procedure
3 trials
Pembrolizumab Biological
3 trials

US sites by state

Facility locations filed on Stage IIIC Lung Cancer AJCC v8 trials. A trial with sites in several states counts in each.

California 11 trials
Texas 7 trials
Arkansas 4 trials
Arizona 3 trials
Ohio 2 trials
New York 2 trials
Alabama 2 trials
Alaska 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Stage IIIC Lung Cancer AJCC v8 page

23 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Stage IIIC Lung Cancer AJCC v8 condition card totals 23 registered trials; most-linked intervention Carboplatin; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.