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2026 data Public-data reference. official source

Stage IIIC Lung Cancer AJCC v8

Open-data reference.

23 US clinical trials · 6 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 304 participants

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

National Cancer Institute (NCI)

NCT06096844

RECRUITING NA 100 participants

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

M.D. Anderson Cancer Center

NCT05010109

RECRUITING Phase 2 51 participants

Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy

M.D. Anderson Cancer Center

NCT04892953

RECRUITING NA 34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Rutgers, The State University of New Jersey

NCT04751747

RECRUITING Phase 2 30 participants

SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer

University of Washington

NCT05570825

RECRUITING Phase 1 28 participants

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT05136846

ACTIVE NOT RECRUITING Phase 3 660 participants

Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04092283

ACTIVE NOT RECRUITING Phase 3 600 participants

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03793179

ACTIVE NOT RECRUITING Phase 2 82 participants

Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT05096663

ACTIVE NOT RECRUITING Phase 1 59 participants

Niraparib, Temozolomide and Atezolizumab in Treating Patients With Advanced Solid Tumors and Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy

Jonsson Comprehensive Cancer Center

NCT03830918

ACTIVE NOT RECRUITING Phase 1 51 participants

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Roswell Park Cancer Institute

NCT02955290

ACTIVE NOT RECRUITING Phase 1 50 participants

Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04073745

ACTIVE NOT RECRUITING Phase 2 48 participants

Niraparib and Dostarlimab for the Treatment of Small Cell Lung Cancer and Other High-Grade Neuroendocrine Carcinomas

M.D. Anderson Cancer Center

NCT04701307

ACTIVE NOT RECRUITING NA 42 participants

A Nurse-Led Intervention for Fear of Progression in Advanced Cancer

City of Hope Medical Center

NCT04819997

ACTIVE NOT RECRUITING Phase 1 37 participants

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

M.D. Anderson Cancer Center

NCT03225664

ACTIVE NOT RECRUITING Phase 1 32 participants

Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT05017025

ACTIVE NOT RECRUITING Phase 2 25 participants

Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03637816

ACTIVE NOT RECRUITING Phase 1 12 participants

Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04837716

ACTIVE NOT RECRUITING Phase 1 8 participants

Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer

City of Hope Medical Center

NCT05166616

ACTIVE NOT RECRUITING Phase 1 6 participants

Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

University of California, Irvine

NCT05334329

ACTIVE NOT RECRUITING Phase 1 5 participants

Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC

City of Hope Medical Center

NCT04227028

ACTIVE NOT RECRUITING Phase 2 5 participants

Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer

University of Southern California

NCT05340309

COMPLETED NA 38 participants

Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer

City of Hope Medical Center

NCT03776253

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 6
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IIIC Lung Cancer AJCC v8 Trial Landscape

ClinicalTrials.gov lists 23 US studies indexed under Stage IIIC Lung Cancer AJCC v8, and 6 of those are currently open to recruitment — roughly 26% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Stage IIIC Lung Cancer AJCC v8 shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Stage IIIC Lung Cancer AJCC v8 is led by M.D. Anderson Cancer Center with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 23 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IIIC Lung Cancer AJCC v8?

PlainTrial tracks 23 US clinical trials for Stage IIIC Lung Cancer AJCC v8, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IIIC Lung Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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