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RECRUITING Phase 3

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

NCT06096844 · View on ClinicalTrials.gov ↗

Study Summary

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

Interventions

  • DRUG Carboplatin
  • PROCEDURE Computed Tomography
  • PROCEDURE Magnetic Resonance Imaging
  • DRUG Paclitaxel
  • DRUG Nab-paclitaxel

Study Locations (20)

California

  • Kaiser Permanente Dublin — Dublin
  • Kaiser Permanente-Fremont — Fremont
  • Kaiser Permanente Fresno Orchard Plaza — Fresno
  • Kaiser Permanente-Fresno — Fresno
  • Kaiser Permanente- Modesto MOB II — Modesto
  • Kaiser Permanente-Modesto — Modesto
  • Kaiser Permanente-Oakland — Oakland
  • VA Palo Alto Health Care System — Palo Alto
  • Kaiser Permanente-Roseville — Roseville
  • Kaiser Permanente Downtown Commons — Sacramento
  • Kaiser Permanente-South Sacramento — Sacramento
  • Kaiser Permanente-San Francisco — San Francisco
  • Kaiser Permanente-Santa Teresa-San Jose — San Jose
  • Kaiser Permanente San Leandro — San Leandro
  • Kaiser San Rafael-Gallinas — San Rafael
  • Kaiser Permanente Medical Center - Santa Clara — Santa Clara

Arkansas

  • Highlands Oncology Group - Fayetteville — Fayetteville
  • Mercy Hospital Fort Smith — Fort Smith
  • Highlands Oncology Group - Rogers — Rogers
  • Highlands Oncology Group — Springdale

Trial Details

FieldValue
Enrollment Target 304 participants
Start Date 2024-07-19
Est. Completion 2026-06-01
Phase Phase 3

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06096844

The ClinicalTrials.gov registry entry for NCT06096844 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 304 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Stage IV Lung Cancer AJCC v8 appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06096844 reports 20 study locations spanning 2 distinct geographic areas — top geographies include California, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06096844 about?

NCT06096844 is a clinical study titled "Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial". This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and m...

What is the current status of trial NCT06096844?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 304 participants. The study started on 2024-07-19. Estimated completion is 2026-06-01.

What conditions does trial NCT06096844 study?

This clinical trial studies the following conditions: Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Advanced Lung Non-Small Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06096844?

The interventions under investigation include: Carboplatin (DRUG), Computed Tomography (PROCEDURE), Magnetic Resonance Imaging (PROCEDURE), Paclitaxel (DRUG), Nab-paclitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06096844?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06096844 being conducted?

This trial has 20 study locations across Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial