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ClinicalTrials.gov official registry

Stage IIIB Non-small Cell Lung Cancer clinical trials

All 17 indexed Stage IIIB Non-small Cell Lung Cancer trials have closed enrollment.

17 US clinical trials ·

Stage IIIB Non-small Cell Lung Cancer is the subject of 17 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 0 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 9 of these trials.

The research picture

Stage IIIB Non-small Cell Lung Cancer has 17 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
9
top sponsor: National Cancer Institute (NCI)
Phase 16Phase 29

Active & Recent Trials

17 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 2 38 participants

CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer

Alliance Foundation Trials

NCT04062708

ACTIVE NOT RECRUITING NA 29 participants

Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery

Jonsson Comprehensive Cancer Center

NCT01345851

COMPLETED NA 129 participants

Erlotinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00085280

COMPLETED Phase 1 94 participants

Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00387465

COMPLETED Phase 2 80 participants

Erlotinib and Celecoxib in Treating Patients With Stage IIIB or Stage IV Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00062101

COMPLETED Phase 2 65 participants

S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00087412

COMPLETED Phase 2 60 participants

Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer

Susanne Arnold

NCT00247416

COMPLETED Phase 2 50 participants

CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00079235

COMPLETED Phase 2 48 participants

Tipifarnib, Gemcitabine, and Cisplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00055757

COMPLETED Phase 2 43 participants

Effect of Pembrolizumab With or Without Carboplatin and Paclitaxel on Immune Response in Patients With Recurrent or Stage IIIB-IV Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT02581943

COMPLETED Phase 2 42 participants

Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer

National Cancer Institute (NCI)

NCT00118144

COMPLETED Phase 1 34 participants

Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00052338

COMPLETED Phase 1 23 participants

Pembrolizumab, Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-IIIB Non-Small Cell Lung Cancer

Rutgers, The State University of New Jersey

NCT02621398

COMPLETED Phase 1 18 participants

Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00778167

COMPLETED Early Phase 1 10 participants

Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Stage III-IV Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT01781741

COMPLETED Phase 1 9 participants

Study of S-3304 in Patients With Locally Advanced Non-Small Cell Lung Cancer

Shionogi

NCT00078390

COMPLETED Phase 2 7 participants

18F-FSPG PET/CT for Cancer Patients on Therapy

Andrei Iagaru

NCT02599194

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IIIB Non-small Cell Lung Cancer Trial Landscape

17 indexed Stage IIIB Non-small Cell Lung Cancer studies · 0 recruiting (0%).

Phase mix: 0 late (III/IV) vs 15 early (I/II).

Top sponsor: National Cancer Institute (NCI) (9 trials), 8 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IIIB Non-small Cell Lung Cancer?

PlainTrial tracks 17 US clinical trials for Stage IIIB Non-small Cell Lung Cancer, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IIIB Non-small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.