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ClinicalTrials.gov 7 recruiting now official registry

Stage III Renal Cell Cancer AJCC v8 clinical trials

7 of 15 indexed Stage III Renal Cell Cancer AJCC v8 trials are currently recruiting.

15 US clinical trials · 7 currently recruiting

Stage III Renal Cell Cancer AJCC v8 is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.

The research picture

Stage III Renal Cell Cancer AJCC v8 has 15 registered US clinical trials, 7 of them open to new participants right now, about 47% of the total.

7
recruiting participants now
47%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: National Cancer Institute (NCI)
Phase 15Phase 29Phase 31

Active & Recent Trials

15 total, page 1 of 1

RECRUITING Phase 2 240 participants

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

NRG Oncology

NCT05327686

RECRUITING Phase 2 65 participants

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

National Cancer Institute (NCI)

NCT04981509

RECRUITING Phase 1 56 participants

Imaging of Solid Tumors Using 18F-TRX

Rahul Aggarwal

NCT06942104

RECRUITING Phase 1 55 participants

Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON Trial

University of Michigan Rogel Cancer Center

NCT06866262

RECRUITING Phase 2 54 participants

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

Vanderbilt-Ingram Cancer Center

NCT05361720

RECRUITING Phase 1 33 participants

Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer

City of Hope Medical Center

NCT07128680

RECRUITING Phase 1 28 participants

CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

Osel

NCT06399419

ACTIVE NOT RECRUITING Phase 3 1,175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

National Cancer Institute (NCI)

NCT03793166

ACTIVE NOT RECRUITING Phase 2 90 participants

Lenvatinib With Everolimus Versus Cabozantinib for Second-Line or Third-Line Treatment of Metastatic Renal Cell Cancer

M.D. Anderson Cancer Center

NCT05012371

ACTIVE NOT RECRUITING Phase 2 60 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

National Cancer Institute (NCI)

NCT03284385

ACTIVE NOT RECRUITING Phase 1 31 participants

CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

City of Hope Medical Center

NCT05122546

ACTIVE NOT RECRUITING Phase 2 30 participants

Ixazomib, Gemcitabine, and Doxorubicin in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

M.D. Anderson Cancer Center

NCT03587662

ACTIVE NOT RECRUITING Phase 2 22 participants

Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney Cancer

Emory University

NCT04022343

ACTIVE NOT RECRUITING Phase 2 18 participants

Perioperative Lenvatinib With Pembrolizumab in Patients With Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma

Emory University

NCT04393350

ACTIVE NOT RECRUITING Phase 2 15 participants

A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)

National Cancer Institute (NCI)

NCT03595124

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 9
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage III Renal Cell Cancer AJCC v8 Trial Landscape

15 indexed Stage III Renal Cell Cancer AJCC v8 studies · 7 recruiting (47%).

Phase mix: 1 late (III/IV) vs 14 early (I/II).

Top sponsor: National Cancer Institute (NCI) (4 trials), 8 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage III Renal Cell Cancer AJCC v8?

PlainTrial tracks 15 US clinical trials for Stage III Renal Cell Cancer AJCC v8, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage III Renal Cell Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.