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Spasticity, Muscle clinical trials
7 of 12 indexed Spasticity, Muscle trials are currently recruiting.
12 US clinical trials · 7 currently recruiting
Spasticity, Muscle is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 2 of these trials.
The research picture
Spasticity, Muscle has 12 registered US clinical trials, 7 of them open to new participants right now, about 58% of the total.
- 7
- recruiting participants now
- 58%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Medical University of South Carolina
Active & Recent Trials
12 total, page 1 of 1
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
Boston Children's Hospital
NCT05354622
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
Kessler Foundation
NCT05432999
Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity
Shepherd Center, Atlanta GA
NCT05429736
Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning
Medical University of South Carolina
NCT05094362
Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy
Ohio State University
NCT06070233
Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
University of Mississippi Medical Center
NCT05457205
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
Elpida Therapeutics SPC
NCT05518188
A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS
RVL Pharmaceuticals
NCT03319732
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
University of Texas Southwestern Medical Center
NCT05103202
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity
Vanderbilt University Medical Center
NCT03209960
Using Telemedicine to Improve Spasticity Diagnosis Rates
Vanderbilt University Medical Center
NCT03211390
DDN in Stroke--COBRE
Medical University of South Carolina
NCT05196737
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Spasticity, Muscle Trial Landscape
12 indexed Spasticity, Muscle studies · 7 recruiting (58%).
Phase mix: 1 late (III/IV) vs 1 early (I/II).
Top sponsor: Medical University of South Carolina (2 trials), 9 others listed. 12 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Spasticity, Muscle?
PlainTrial tracks 12 US clinical trials for Spasticity, Muscle, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Spasticity, Muscle?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.