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ClinicalTrials.gov 9 recruiting now early-phase tilt

Social Isolation: early-phase trial registry

9 of 25 indexed Social Isolation trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #652 of 28,707 conditions by registered trial count.

25 US clinical trials · 9 currently recruiting · #652 of 28,707 conditions by registered trial count

Social Isolation: 25 US clinical trials tracked, 9 recruiting.

Social Isolation is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is University of Rochester, running 4 of these trials.

Enrollment posture brief

Registry condition social-isolation

OPEN 9 | RECR 36% | LATE 0 | EARLY 1 | RANK #652 | SPON 4

Nearest open-share peer: Cannabis (36% recruiting · 25 trials)

Alpha-1 Antitrypsin Deficien48%Alcohol Use40%Acute Lymphocytic Leukemia36%Alcohol-Related Disorders36%Social Isolation (this)36%
Open-enrollment share among volume-matched conditions near Social Isolation

Social Isolation lists 9 open slots (36% of 25 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Social Isolation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Social Isolation is recruiting below its size-band peers.

    9 of 25 indexed trials (36%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Social Isolation research.

    University of Rochester accounts for 4 of 25 trials (16%). 19 distinct sponsors appear on at least one study for this condition label.

  3. Typical Social Isolation enrolment sits around 120 participants.

    Median target enrolment is 120 among the 25 trials that report a genuine target (sentinel values excluded). 12 of those (48%) plan for fewer than 100 participants.

  4. Social Isolation research is mostly interventional.

    25 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 21

Open and recent trials

25 total, page 1 of 1

RECRUITING NA 450 participants

CAPABLE Care + Connect

Johns Hopkins University

NCT07123298

RECRUITING NA 300 participants

Intervening on Opioid Use and Loneliness

University of Rochester

NCT06458335

RECRUITING NA 264 participants

Increasing Veterans' Social Engagement and Connectedness

VA Office of Research and Development

NCT06467214

RECRUITING NA 250 participants

Sisters of Heart (Hermanas de Corazón): A Community Health Worker Initiative for Improving Heart Health in Migrant Farmworker Women

Emory University

NCT07111026

RECRUITING NA 120 participants

Need to be Needed (N2BN) Intervention

Temple University

NCT06510439

RECRUITING NA 80 participants

LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation

Cedars-Sinai Medical Center

NCT05831475

RECRUITING NA 66 participants

Qnnections: Refinement and Pilot Trial of a Suicide Prevention Intervention to Increase Social Connection

VA Office of Research and Development

NCT06803329

RECRUITING NA 65 participants

Fostering Agricultural Relationships and Meaning - Thriving on Kinship

Ohio State University

NCT07218965

RECRUITING NA 30 participants

The VESPA Pilot Study

Wake Forest University

NCT04756245

ACTIVE NOT RECRUITING NA 369 participants

Digital Nutrition Intervention for Older Adults

The University of Texas at San Antonio

NCT05220631

ACTIVE NOT RECRUITING NA 60 participants

Social Prescribing and Relationship Cognitive Strategies (SPARCS)

University of Michigan

NCT06656975

COMPLETED NA 671 participants

The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)

University of Florida

NCT07204444

COMPLETED NA 671 participants

The Impact of Community Exercise on Social Connectedness and Falls in Older Adults: Leveraging Exercise to Age in Place

Cedars-Sinai Medical Center

NCT03624049

COMPLETED NA 418 participants

Rural Dementia Caregiver Project

University of California, San Francisco

NCT04428112

COMPLETED NA 240 participants

Telephone Calls for Health for Homebound Older Adults

University of Texas at Austin

NCT04595708

COMPLETED NA 197 participants

Bridging Community Gaps Photovoice

Boston University Charles River Campus

NCT03291717

COMPLETED Phase 2 183 participants

Peer Support Intervention to Mitigate Social Isolation and Stigma of Adolescent Motherhood in Zimbabwe

West Chester University of Pennsylvania

NCT05213182

COMPLETED NA 124 participants

Blue Star Cares: Innovative Approaches to Helping Military-Connected Caregivers

University of Southern California

NCT03336190

COMPLETED NA 98 participants

Mobilizing Community Networks to Optimize Child Well-being

Boston Medical Center

NCT02622399

COMPLETED NA 68 participants

"Recovery 4 US" - A Photovoice-based Social Media Program

Boston University Charles River Campus

NCT03266614

COMPLETED NA 64 participants

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

George Mason University

NCT04281654

COMPLETED NA 54 participants

Culture and Well-Being for Latinos

University of Rochester

NCT05244733

COMPLETED NA 29 participants

Study 1: Social Engage Coaching R61 Phase

University of Rochester

NCT05745493

COMPLETED NA 25 participants

Social Functions to Promote Home-based Cognitive Training

Florida State University

NCT06175299

COMPLETED NA 5 participants

Connect for Caregivers

University of Rochester

NCT04919070

Phase Distribution

PhaseTrial count
Phase 2 1

Named interventions

Most-linked intervention names on Social Isolation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Cognitive-Behavioral Therapy for Perceived Social Isolation Behavioral
2 trials
Health Education Behavioral
2 trials
Young Women of Today Behavioral
1 trials
avatar-based training Behavioral
1 trials
Connect for Caregivers Behavioral
1 trials
Active Social Conversation Other
1 trials
Building Better Caregivers Workshop Behavioral
1 trials
Bridging Community Gaps Photovoice (BCGP) Behavioral
1 trials

US sites by state

Facility locations filed on Social Isolation trials. A trial with sites in several states counts in each.

New York 4 trials
California 4 trials
Massachusetts 3 trials
Texas 2 trials
Pennsylvania 2 trials
Maryland 2 trials
Georgia 2 trials
Virginia 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Social Isolation page

25 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Social Isolation condition card totals 25 registered trials; most-linked intervention Cognitive-Behavioral Therapy for Perceived Social Isolation; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.