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ClinicalTrials.gov 8 recruiting now official registry

Smoldering Multiple Myeloma clinical trials

8 of 21 indexed Smoldering Multiple Myeloma trials are currently recruiting.

21 US clinical trials · 8 currently recruiting

Smoldering Multiple Myeloma is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 6 of these trials.

The research picture

Smoldering Multiple Myeloma has 21 registered US clinical trials, 8 of them open to new participants right now, about 38% of the total.

8
recruiting participants now
38%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: Dana-Farber Cancer Institute
Phase 11Phase 28Phase 33

Active & Recent Trials

21 total, page 1 of 1

RECRUITING 10,000 participants

Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

Dana-Farber Cancer Institute

NCT02269592

RECRUITING 2,000 participants

Registry for Adults With Plasma Cell Disorders (PCD's)

UNC Lineberger Comprehensive Cancer Center

NCT03717844

RECRUITING 1,000 participants

Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions

University of Miami

NCT05361694

RECRUITING 400 participants

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Tufts Medical Center

NCT06365060

RECRUITING NA 150 participants

A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

Memorial Sloan Kettering Cancer Center

NCT05640843

RECRUITING 100 participants

Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial

University of Utah

NCT06212323

RECRUITING Phase 2 52 participants

Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

Irene Ghobrial, MD

NCT05469893

RECRUITING Phase 2 15 participants

Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myeloma

University of Rochester

NCT05597345

ACTIVE NOT RECRUITING 656 participants

Questionnaire and Tissue Banking For Multiple Myeloma, Waldenstrom Macroglobulinemia and Related Disorders

Dana-Farber Cancer Institute

NCT01177527

ACTIVE NOT RECRUITING Phase 3 460 participants

Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

National Cancer Institute (NCI)

NCT00114101

ACTIVE NOT RECRUITING Phase 3 390 participants

A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myeloma

Janssen Research & Development

NCT03301220

ACTIVE NOT RECRUITING Phase 3 226 participants

Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma

National Cancer Institute (NCI)

NCT01169337

ACTIVE NOT RECRUITING NA 201 participants

Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program

Case Comprehensive Cancer Center

NCT05831358

ACTIVE NOT RECRUITING Phase 2 87 participants

Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant

International Myeloma Foundation

NCT03289299

ACTIVE NOT RECRUITING Phase 2 60 participants

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Dana-Farber Cancer Institute

NCT04850846

ACTIVE NOT RECRUITING Phase 2 42 participants

Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple Myeloma

Dana-Farber Cancer Institute

NCT03236428

ACTIVE NOT RECRUITING NA 23 participants

A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

Memorial Sloan Kettering Cancer Center

NCT04920084

ACTIVE NOT RECRUITING Phase 2 20 participants

CAR- PRISM (PRecision Intervention Smoldering Myeloma)

Dana-Farber Cancer Institute

NCT05767359

ACTIVE NOT RECRUITING Phase 1 19 participants

A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM

Massachusetts General Hospital

NCT02886065

COMPLETED Phase 2 61 participants

Trial of Combination of Ixazomib and Lenalidomide and Dexamethasone in Smoldering Multiple Myeloma

Dana-Farber Cancer Institute

NCT02916771

COMPLETED Phase 2 30 participants

Study on the Anti-tumor Activity, Safety and Pharmacology of IPH2101 in Patients With Smoldering Multiple Myeloma

Innate Pharma

NCT01222286

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 8
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoldering Multiple Myeloma Trial Landscape

21 indexed Smoldering Multiple Myeloma studies · 8 recruiting (38%).

Phase mix: 3 late (III/IV) vs 9 early (I/II).

Top sponsor: Dana-Farber Cancer Institute (6 trials), 9 others listed. 21 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoldering Multiple Myeloma?

PlainTrial tracks 21 US clinical trials for Smoldering Multiple Myeloma, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoldering Multiple Myeloma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.