Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Sleep Deprivation

Open-data reference.

35 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING NA 180 participants

Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)

University of Arizona

NCT05588934

RECRUITING NA 160 participants

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

Yale University

NCT05551325

RECRUITING NA 120 participants

Nighttime Synchrony of Your Nutrition and Circadian Health

University of Utah

NCT07329283

RECRUITING NA 100 participants

The Function of Biphasic Sleep in Infants

University of Massachusetts, Amherst

NCT06399939

RECRUITING NA 100 participants

Menstrual-phase-dependent Differences in Response to Sleep Loss

Brigham and Women's Hospital

NCT05381532

RECRUITING NA 100 participants

Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

Pennington Biomedical Research Center

NCT06070194

RECRUITING NA 100 participants

The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

Beth Israel Deaconess Medical Center

NCT03767426

RECRUITING NA 90 participants

Mind After Midnight

University of Arizona

NCT07438912

RECRUITING NA 90 participants

The Effect of Sleep Loss on Emotion Regulation

Beth Israel Deaconess Medical Center

NCT05393830

RECRUITING NA 70 participants

Effect of Sleep Extension on Ceramides in People with Overweight and Obesity

University of Utah

NCT06180837

RECRUITING 60 participants

Immune Status After Being on Call for 24 Hrs

University of Chicago

NCT06636318

RECRUITING NA 60 participants

Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators

Beth Israel Deaconess Medical Center

NCT05026541

RECRUITING NA 60 participants

Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Ohio State University

NCT06075914

RECRUITING NA 60 participants

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction

Ohio State University

NCT05519644

RECRUITING NA 55 participants

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

Rhode Island Hospital

NCT06737055

RECRUITING NA 46 participants

Biomarkers of Increased Free Living Sleep Time

University of Utah

NCT04214184

RECRUITING NA 44 participants

Acoustic Stimulation During Restricted Sleep After Sleep Deprivation

Walter Reed Army Institute of Research (WRAIR)

NCT05309473

RECRUITING NA 40 participants

Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep

U.S. Army Medical Research and Development Command

NCT02945501

RECRUITING NA 20 participants

Sleep and Metabolism

Oregon Health and Science University

NCT05775627

COMPLETED 771 participants

Understanding Sleep in Hospitalized Older Patients

University of Chicago

NCT01057823

COMPLETED NA 180 participants

Impact of Sleep Workshops in College Students

NYU Langone Health

NCT02665247

COMPLETED NA 100 participants

Mechanisms of Sleep Disruption Hyperalgesia

Johns Hopkins University

NCT01794689

COMPLETED Phase 4 100 participants

Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?

Maisonneuve-Rosemont Hospital

NCT01791296

COMPLETED NA 90 participants

Impact of Bed Provision and Sleep Education

Saint Joseph's University, Philadelphia

NCT04536766

COMPLETED NA 84 participants

A Study of the Effectiveness and Efficacy of the PowerSleep Device

Philips Respironics

NCT03162328

COMPLETED NA 46 participants

Olfactory Decision-making and Deprived Sleep

Northwestern University

NCT05093413

COMPLETED NA 44 participants

Are Bright Lights and Regulated Sleep Effective Treatment for Depression?

New York State Psychiatric Institute

NCT03010488

COMPLETED NA 24 participants

Sleep Chatbot Intervention for Emerging Black/African American Adults

University of Delaware

NCT05956886

COMPLETED NA 23 participants

Effect of Total Sleep Deprivation on Vascular Function

University of Florida

NCT04535219

COMPLETED NA 22 participants

Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control

Brigham and Women's Hospital

NCT02755493

COMPLETED NA 15 participants

Implementing Behavioral Sleep Intervention in Urban Primary Care

Children's Hospital of Philadelphia

NCT04046341

COMPLETED NA 12 participants

Biomarkers of Insufficient Sleep and Sleepiness

University of Colorado, Boulder

NCT03130803

COMPLETED NA 10 participants

Circadian Rhythm Disruption Effects on Smoke Inhalation

University of Montana

NCT04955431

COMPLETED NA 10 participants

Sleep Restriction and Postprandial Lipemia

University of Missouri-Columbia

NCT05713370

COMPLETED NA 7 participants

White Noise to Improve Sleep in the Medical Intensive Care Unit (MICU): a Pilot and Feasibility Study

Yale University

NCT03755011

Phase Distribution

PhaseTrial count
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sleep Deprivation Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Sleep Deprivation, and 19 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Sleep Deprivation shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Sleep Deprivation is led by University of Utah with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sleep Deprivation?

PlainTrial tracks 35 US clinical trials for Sleep Deprivation, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sleep Deprivation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →