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NCT04955431 · ClinicalTrials.gov registry record · NA
Circadian Rhythm Disruption Effects on Smoke Inhalation
A NA study of Inflammation and Sleep Deprivation, sponsored by University of Montana.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04955431: Completed NA study of Inflammation and Sleep Deprivation, sponsored by University of Montana.
NCT04955431 is a NA study of Inflammation and Sleep Deprivation that has completed, run by University of Montana. The registered enrollment target is 10 participants, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04955431, a NA study of Inflammation and Sleep Deprivation, has completed, sponsored by University of Montana.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians. Persistent occupational exposure to particulate matter represents a unique hazard for firefighters, underpinning a burgeoning research area. This trial will evaluate the effects of sleep deprivation and circadian rhythm disruption on the inflammatory response to woodsmoke associated particulate matter exposure. Participants will undergo 2 experimental trials in a randomized cross-over design. Participants will have either an 8-hour sleep opportunity or a 4-hour sleep opportunity prior to reporting to lab for a 45 minute simulated firefighting trial (wood smoke associated particulate matter filtered to 2.5 um at a concentration of 250 ug/m\^3, while exercising at a moderate intensity). The effects of sleep restriction and simulated firefighting will be measured.
Primary Outcome
IL-6 will be measured in the plasma
Conditions Studied
Interventions
- BEHAVIORAL Sleep Restriction
- BEHAVIORAL Normal Sleep
Study Locations (1)
Montana
- School of Integrative Physiology and Athletic Training - Missoula
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-01-24 |
| Est. Completion | 2022-04-17 |
| Phase | NA |
What the finished NCT04955431 record still lists
NCT04955431 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Inflammation appearing as the primary indexed condition, and to 2 interventions - of which Sleep Restriction is the first listed.
NCT04955431 reports a single indexed study location in Montana.
Frequently Asked Questions
What is clinical trial NCT04955431 about?
NCT04955431 is a clinical study titled "Circadian Rhythm Disruption Effects on Smoke Inhalation". Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians. Persistent occupational exposure to particulate matter represents a unique hazard for firefighters, underpinning a burgeoning researc...
What is the current status of trial NCT04955431?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2022-01-24. Estimated completion is 2022-04-17.
What conditions does trial NCT04955431 study?
This clinical trial studies the following conditions: Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation.
What interventions are being tested in trial NCT04955431?
The interventions under investigation include: Sleep Restriction (BEHAVIORAL), Normal Sleep (BEHAVIORAL).
Who is sponsoring clinical trial NCT04955431?
This trial is sponsored by University of Montana, which has 24 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04955431 being conducted?
This trial has 1 study location across Montana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04955431's enrollment target sits among peer trials
10 128th of 132 higher than 2 of 132 other Inflammation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Inflammation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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