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NCT06636318 · ClinicalTrials.gov registry record
Immune Status After Being on Call for 24 Hrs
A clinical trial of Sleep Deprivation, sponsored by University of Chicago.
- Recruiting
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT06636318: Recruiting study of Sleep Deprivation, sponsored by University of Chicago.
NCT06636318 is a study of Sleep Deprivation that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 60 participants, below the 89-participant average among 34 other Sleep Deprivation trials with a reported enrollment target (33% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06636318, a study of Sleep Deprivation, is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes. Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.
Primary Outcome
Specifically, T cells, B cells, dendritic cells, macrophages, and natural killer cells will be identified and analyzed. Memory cells, co-inhibitor markers, and regulatory markers will also be evaluated. The function will be analyzed based on the intracellular expression of effector molecules and cytokines after unspecific activation with CD3-CD28 beads.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Blood Sample Collection
- DEVICE Actigraph (GT9X-BT) Monitor
Study Locations (1)
Illinois
- The University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-10-17 |
| Est. Completion | 2027-12 |
What NCT06636318 shows while recruiting
NCT06636318 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 89-participant average among 34 other Sleep Deprivation trials with a reported enrollment target (33% lower).
The record links to 1 condition, with Sleep Deprivation appearing as the primary indexed condition, and to 2 interventions - of which Blood Sample Collection is the first listed.
NCT06636318 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06636318 about?
NCT06636318 is a clinical study titled "Immune Status After Being on Call for 24 Hrs". Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experienci...
What is the current status of trial NCT06636318?
This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2024-10-17. Estimated completion is 2027-12.
What conditions does trial NCT06636318 study?
This clinical trial studies the following conditions: Sleep Deprivation.
What interventions are being tested in trial NCT06636318?
The interventions under investigation include: Blood Sample Collection (DIAGNOSTIC_TEST), Actigraph (GT9X-BT) Monitor (DEVICE).
Who is sponsoring clinical trial NCT06636318?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06636318 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sleep Deprivation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06636318's enrollment target sits among peer trials
60 17th of 34 higher than 15 of 34 other Sleep Deprivation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sleep Deprivation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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